Publications by authors named "Janany Kandiah"
Down syndrome (DS) is a genetic disease characterized by a supernumerary chromosome 21. Intellectual deficiency (ID) is one of the most prominent features of DS. Central nervous system defects lead to learning disabilities, motor and language delays, and memory impairments.
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- Intensive insulin therapy is effective for managing diabetes but can lead to dangerous hypoglycemia, primarily detected by the ventromedial hypothalamus (VMH) in the brain.
- The study aimed to explore the role of serotonin (5-HT) neurons in regulating the counter-regulatory response (CRR) to hypoglycemia.
- Results indicated that insulin increases activity in dorsal raphe 5-HT neurons and affects glucagon secretion, highlighting a significant role of the serotonin network in responding to insulin-induced low blood sugar levels.
Article Synopsis
- Down syndrome is a common chromosomal disorder associated with blood issues, particularly mild to moderate thrombocytopenia (low platelet count), which doesn't typically lead to bleeding problems.
- Researchers studied the effects of Dyrk1A overexpression in mice and found it resulted in a 20% decrease in platelet count and a surprising 50% reduction in bleeding time.
- The study revealed that the changes were linked to increased levels of fibronectin and fibrinogen in the plasma and liver, suggesting Dyrk1A has a new role in promoting these proteins, which may explain the observed discrepancies in bleeding tendencies.
Article Synopsis
- Plant-derived polyphenols, especially flavonoids, are being explored for their medicinal benefits due to their low toxicity and minimal side effects.
- Catechins, a significant group of flavonoids, show promise in treating various issues linked to Down syndrome, a genetic disorder often accompanied by intellectual disabilities and increased risk for Alzheimer's disease and obesity.
- This review focuses on the impact of catechins on conditions associated with Down syndrome and their effects on the DYRK1A gene, which is crucial in relation to brain and metabolic disorders.