The tolerance to chemoradiation for cervical cancer patients: A comparative prospective study of rural versus urban population.

Context: Rural versus urban cervical cancer.

Aims: This study aims to study the difference in toxicities and clinical outcome of chemoradiation in urban and rural cervical cancer patient.

Settings And Design: This was a prospective study.

Equivalent dose in 2 Gy (EQD2) to pelvic lymph nodes using volume based prescription for three brachytherapy applicators - a dosimetric retrospective analysis.

Background: Pelvic lymph node (PLN) metastasis has been included in the FIGO staging, so there is a need to determine the dose contribution from brachytherapy to ascertain the total delivered dose to the pelvic lymph nodes in cervical cancer. The aim of the study was to calculate the equivalent dose in 2 Gy (EQD2) of the pelvic lymph nodes (PLNs) based on volume prescription using three applicators.

Materials And Methods: Forty-one patients who had undergone external beam radiotherapy followed by brachytherapy using tandem ovoids (TO), tandem ring (TR) and TO + free hand interstitial needles (TO + FH) applicators were taken for this study.

Interstitial high-dose-rate brachytherapy using cobalt-60 source for cervical cancer: dosimetric and clinical outcomes from a single institute.

Purpose: To record and report dosimetric and clinical outcomes of interstitial brachytherapy using cobalt-60 (Co) source in cervical cancer.

Material And Methods: Seventy patients who underwent external beam radiotherapy with dose of 45 Gy in 25 fractions, followed by interstitial brachytherapy (ISBT) 6.5 Gy × 4 fractions were included into this study.

One thousand cases of cobalt-based high dose rate brachytherapy treated at a tertiary care center: A retrospective study.

Purpose: This is a study of our experience with Co-60 high dose rate brachytherapy (HDR BT) from a tertiary care center.

Materials And Methods: One thousand patients were treated with Cobalt-based HDR BT for more than 6 years. The practice of BT was analyzed for clinical outcome, physical, radiobiological, and technical aspects.

Predicting toxicity for head and neck cancer patients undergoing radiation therapy: an independent and external validation of MDASI-HN based nomogram.

Aim: We conducted a study to validate the MDASI-HN based nomogram, which is used to predict the acute toxicities in head and neck cancer patients undergoing radiation therapy with or without chemotherapy.

Background: Tolerance to radiation varies from patient to patient and also depends on various other factors like tumor volume, dose of radiation, chemotherapy. Predicting the toxicities allow us to identify potential candidates who are likely to have a higher toxicity and, in addition, evaluates the nomogram when done on an independent group of patients.

Implications of bladder volume on target coverage and dose to critical structures during high dose rate intracavitary brachytherapy for cervical cancer: A dosimetric study.

Background: The distension of the bladder during intracavitary brachytherapy (ICBT) affects the applicator position and in turn the dose to tumour and normal structures.

Aims And Objectives: To quantify the changes in the dose to high risk clinical target volume (HRCTV) and organs at risk (OARs) due to bladder filling.

Methods And Materials: In this prospective study, dosimetric parameters of 40 cervical cancer patients treated with (ICBT) were studied.

Inter-institutional comparison of treatment practice for cervical cancer with special emphasis on brachytherapy.

Purpose: To compare the cervical cancer treatment outcome and toxicities between two different institutions.

Material And Methods: We analysed the clinical outcome of cervical cancer patients treated at two different centres from January 2015 to December 2016. Centre A treated 72 patients by external beam radiotherapy (EBRT) to a dose of 45 Gy in 25 fractions followed by intracavitary brachytherapy (ICBT) 6.

Compliance with bladder protocol during concurrent chemoradiation for cancer of the cervix and its impact on enteritis: A prospective observational study.

Aim: This prospective study aims to assess the compliance with bladder protocol and the correlation with enteritis during pelvic radiation.

Background: Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume especially in the last two weeks due to radiation enteritis and cystitis.

Does fall in serum glutathione predict the long-term outcome to concurrent chemoradiation for cervical cancer patients?

Background: Wide variations are seen in clinical practice with respect to response to concurrent chemo radiation among cervical cancer patients. Fall in serum glutathione (GSH) level directly correlates with early response to treatment. Whether this early response translates to a better long term outcome is the subject of this prospective study.

Comprehensive assessment of Somnolence Syndrome in patients undergoing radiation to the brain.

Aim: The aim of this prospective study was to assess Somnolence Syndrome (SS) in patients undergoing radiation to the brain.

Background: SS is one of the sequelae of radiation to the brain, which is observed within three months of radiation. This is a self-limiting condition and a failure to diagnose leads to unnecessary investigations.

The nuances of brachytherapy taught by teachers from beyond: Questionnaire-based assessment of the first cadaveric hands-on brachytherapy workshop in India.

Purpose: A questionnaire-based assessment of a cohort of young radiation oncologists attending the first human cadaveric hands-on brachytherapy workshop in India.

Methods And Materials: The cadaveric workshop for hands-on training in head/neck and gynecologic cancers was a novel process conducted at M.S.

Implication of Bifurcation of Abdominal Aorta for Radiotherapy Planning for Cervical Cancers.

Introduction: External Beam Radiotherapy plays a major role in the management of Carcinoma Cervix. The Radiotherapy treatment portals are designed to adequately cover the gross disease and areas of microscopic spread. The upper border of Radiotherapy field is traditionally placed at the level of L4-L5 intervertebral space to cover the common iliac nodal area.

Comparison of manual and inverse optimisation techniques in high dose rate intracavitary brachytherapy of cervical cancer: A dosimetric study.

Aims And Objectives: To compare dosimetrically the manual optimisation with IPSA using dose volume histograms (DVH) among patients treated for carcinoma of cervix with intracavitary brachytherapy.

Background: With the advent of advanced imaging modalities, there has been a shift from conventional X-ray based planning to three-dimensional planning. Manual optimisation is widely used across various institutions but it is time consuming and operator dependant.