Study of wound healing in rats treated with topical and injected mitomycin C.

Objectives: Mitomycin C, a widely used chemotherapeutic drug, has been proposed as a potential adjuvant for the control of scar tissue in surgical wounds because of its capacity to inhibit fibroblast proliferation. The current study used a combination of topical and injected mitomycin C to slow the healing process of surgical wounds in rats.

Methods: An experimental model of surgical wounding at the dorsum of rats was used.

Study of wound healing in rats treated with topical and injected mitomycin-C.

Unlabelled: Experimental study in animals.

Introduction: Mitomycin C has been used as a fibroblasts inhibitor, thus reducing the scaring process in surgical wounds.

Aim: This paper aims at assessing the use of Mitomycin C to reduce the scaring process through its topical use and later injected reinforcements.

Clinical and histological healing of surgical wounds treated with mitomycin C.

Objectives/hypothesis: The proven ability of mitomycin C to inhibit fibroblasts in vitro has stimulated its use in research animals and in humans to control healing. The objective of the study was to follow the healing process of surgical wounds in the dorsum of rats treated topically with mitomycin C.

Study Design: Prospective experimental study.