Publications by authors named "Jana Tisonova"
Article Synopsis
- Identifying aging-related changes in vascular tone is crucial for improving cardiovascular disease diagnosis, as various mechanisms like NO synthase activity and sympathetic nervous system activity play roles in this regulation.
- Calcium-dependent chloride channels (CaCCs) significantly affect all aspects of vascular tone regulation, and their activation is linked to both intracellular calcium levels and voltage, which fine-tunes vascular response.
- As individuals age, there's a decline in CaCC activation due to reduced protein levels and impaired calcium influx, which may contribute to the overall alterations in vascular tone regulation.
In the past few years, COVID-19 became the leading cause of morbidity and mortality worldwide. Although the World Health Organization has declared an end to COVID-19 as a public health emergency, it can be expected, that the emerging new cases at the top of previous ones will result in an increasing number of patients with post-COVID-19 sequelae. Despite the fact that the majority of patients recover, severe acute lung tissue injury can in susceptible individuals progress to interstitial pulmonary involvement.
View Article and Find Full Text PDFThe aim of this study was to investigate the influence of trait anxiety and menstrual cycle phase on neuroendocrine activation during combined mental and physical stress procedure in 40 healthy female subjects. Women at the upper (anxious) and lower (nonanxious) limits of the normal range of a trait anxiety scale were exposed to the stress procedure consisting of a mental component (Stroop test) and handgrip exercise. Salivary cortisol levels, cardiovascular parameters, and cognitive performance in the Stroop test were evaluated.
View Article and Find Full Text PDFObjective: The aims of the present study were to: analyse the prevalence of polypharmacy in a group of older patients; evaluate the influence of hospital stay on the number of drugs taken; assess the most frequently prescribed pharmacological classes; identify risk factors that predisposed the patient to polypharmacy. Setting The study was carried out in the Department of Internal Medicine of a non-university general hospital.
Method: In the retrospective study, 600 patients aged 65 years or more were enrolled.