Publications by authors named "Jana Rupp"
Sci Total Environ
June 2023
Article Synopsis
- PFAS (per- and polyfluorinated alkyl substances) are man-made chemicals that don’t break down easily and accumulate in the environment, which was analyzed in various mammal and bird species across Germany and Denmark.
- The study measured PFAS concentrations in 12 mammal species and 2 bird species while considering their diet (herbivores, omnivores, carnivores), habitat (land vs. water), and tissue type (liver vs. muscle).
- Results showed that carnivores had the highest PFAS levels, with significant variation in specific compounds depending on their trophic class and habitat, revealing more complex contamination patterns than previously understood.
Sci Total Environ
May 2023
Article Synopsis
- Researchers analyzed wild boar liver samples from three different areas to assess their ability to indicate PFAS contamination in the environment, focusing on areas with varying levels of pollution.
- A total of 31 PFAS compounds were identified, with significantly higher concentrations found in contaminated sites compared to background levels, particularly with legacy compounds like PFOS and PFOA.
- The study concluded that wild boar livers effectively reflect the local soil contamination, making them useful bioindicators for monitoring PFAS levels in terrestrial ecosystems.
Article Synopsis
- Non-alcoholic steatohepatitis (NASH) is a serious liver disease that causes fat buildup, inflammation, and fibrosis, but currently has no approved treatment.
- Researchers developed a 3D microtissue model using human liver cells that mimics NASH, showing key disease features like increased triglycerides and inflammation within 10 days.
- This model allows for the testing of potential anti-NASH drugs, revealing their effectiveness and changing gene expression patterns, making it a valuable tool for drug discovery and understanding NASH's complexities.
