Publications by authors named "Jana Pokludova"
Article Synopsis
- - Caspase-9 is known for triggering cell death in the intrinsic apoptotic pathway, but recent research has shown that it also plays roles in cell growth, development, and maintaining cellular health beyond apoptosis.
- - A study using advanced proteomics compared protein levels in normal and caspase-9 knockout mouse osteoblasts (MC3T3-E1), identifying a significant number of proteins that were altered—283 were upregulated and 141 were downregulated upon caspase-9 knockout.
- - The changes in protein expression were linked to processes like cell migration and DNA repair, suggesting that caspase-9 influences the movement of osteoblasts, which may have implications for bone healing and remodeling. *
An acidic environment and hypoxia within the tumour are hallmarks of cancer that contribute to cell resistance to therapy. Deregulation of the PI3K/Akt pathway is common in colon cancer. Numerous Akt-targeted therapies are being developed, the activity of Akt-inhibitors is, however, strongly pH-dependent.
View Article and Find Full Text PDFTACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates.
View Article and Find Full Text PDF