O-sensitive microcavity arrays: A new platform for oxygen measurements in 3D cell cultures.

Oxygen concentration plays a crucial role in (3D) cell culture. However, the oxygen content is usually not comparable to the situation, which is partly due to the fact that most experiments are performed under ambient atmosphere supplemented with 5% CO, which can lead to hyperoxia. Cultivation under physiological conditions is necessary, but also fails to have suitable measurement methods, especially in 3D cell culture.