Publications by authors named "Jana Peeters"
Background: Subthalamic deep brain stimulation (STN-DBS) is a well-established therapy to treat Parkinson's disease (PD). However, the STN-DBS sub-target remains debated. Recently, a white matter tract termed the hyperdirect pathway (HDP), directly connecting the motor cortex to STN, has gained interest as HDP stimulation is hypothesized to drive DBS therapeutic effects.
View Article and Find Full Text PDFIntroduction: Symmetric biphasic pulses have been shown to increase the therapeutic window compared to standard cathodic pulses in ET Vim-DBS patients. Furthermore, three hours of stimulation with biphasic pulses caused less stimulation-induced ataxia compared to cathodic pulses. Therefore, an investigation of the longer-term safety of biphasic pulses is warranted.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the effectiveness of short pulse width deep brain stimulation (spDBS) compared to conventional pulse width DBS (cDBS) for treating movement disorders like Parkinson's disease (PD) and essential tremor (ET).
- - Results show that spDBS offers a larger therapeutic window and better tremor reduction in ET, but does not significantly change therapeutic effects or side effects in PD compared to cDBS.
- - Additionally, spDBS requires less energy, potentially improving battery life, though more real-world data is needed on this aspect.
Background: Musician's dystonia is a task-specific focal hand dystonia characterized by involuntary contraction of muscles while playing a musical instrument. Current treatment options are often insufficient.
Observations: We present the effects of ventro-oral thalamic deep brain stimulation in a patient with musician's dystonia.
Article Synopsis
- Subthalamic deep brain stimulation (STN-DBS) is a surgical treatment for Parkinson's disease, but not all patients respond well due to technical complexities and variability in symptom response.
- Researchers recorded DBS-evoked potentials (EPs) and collected brain imaging from 10 patients to develop prediction models for finding the optimal stimulation settings.
- The study found that combining EPs with imaging data significantly improved the ability to predict the best contact configuration for stimulation, which could enhance the DBS programming process in everyday clinical practice.
Article Synopsis
- Symmetric biphasic pulses improve the therapeutic effects of deep brain stimulation (Vim-DBS) for essential tremor (ET) by reducing side effects like ataxia compared to standard cathodic pulses.
- In a study with 12 ET patients, both pulse types provided similar tremor control during a 3-hour stimulation period.
- Results showed that biphasic pulses led to significantly less ataxia and improved speech rates, suggesting a better safety profile for this stimulation method in ET treatment.
Background: Subthalamic deep brain stimulation (DBS) is an established therapy to treat Parkinson's disease (PD). To maximize therapeutic outcome, optimal DBS settings must be carefully selected for each patient. Unfortunately, this is not always achieved because of: (1) increased technological complexity of DBS devices, (2) time restraints, or lack of expertise, and (3) delayed therapeutic response of some symptoms.
View Article and Find Full Text PDFDeep brain stimulation is an established treatment option for both essential tremor (ET) and Parkinson's disease (PD), although typically targeting different brain structures. Some patients are diagnosed with comorbid ET and PD. Selecting the optimal stimulation target in these patients is challenging.
View Article and Find Full Text PDFIntroduction: Symmetric biphasic pulses enlarge the therapeutic window in thalamic deep brain stimulation in patients with essential tremor. Adding an interphase gap to these symmetric biphasic pulses may further affect the therapeutic window.
Materials And Methods: Nine patients (16 hemispheres) were included in this study.
Article Synopsis
- - Deep brain stimulation (DBS), used for treating Parkinson's disease, can generate distinct EEG responses based on specific brain areas stimulated, as shown by different peaks in evoked potentials (P3 and P10) related to stimulation of the dorsolateral subthalamic nucleus and substantia nigra respectively.
- - The study aimed to explore whether the new multiple independent current control (MICC) technology could produce unique neurophysiological responses by precisely adjusting the electric field between DBS contacts.
- - Results indicated that varying the electric field location significantly affected the amplitudes of the P3 and P10 responses, suggesting that MICC could enhance the precision of DBS programming for individual patients.
Background: Since the inception of DBS, cathodic pulses have been used.
Objective: To investigate the effect of anodic and symmetric biphasic pulses on the therapeutic window (TW) in essential tremor (ET) patients.
Methods: A randomized, doubled-blinded, cross-over design was used to test the effect of cathodic, anodic and symmetric biphasic pulses (cathode-first and anode-first) on the TW in an acute clinical setting.
Objectives: Deep brain stimulation (DBS) delivered via multicontact leads implanted in the basal ganglia is an established therapy to treat Parkinson disease (PD). However, the different neural circuits that can be modulated through stimulation on different DBS contacts are poorly understood. Evidence shows that electrically stimulating the subthalamic nucleus (STN) causes a therapeutic effect through antidromic activation of the hyperdirect pathway-a monosynaptic connection from the cortex to the STN.
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