The riboflavin biosynthetic pathway as a novel target for antifungal drugs against species.

Unlabelled: In recent decades, there has been an increase in the occurrence of fungal infections; yet, the arsenal of drugs available to fight invasive infections remains very limited. The development of new antifungal agents is hindered by the restricted number of molecular targets that can be exploited, given the shared eukaryotic nature of fungi and their hosts which often leads to host toxicity. In this paper, we examine the riboflavin biosynthetic pathway as a potential novel drug target.

The Cdc25 and Ras1 Proteins of Influence Epithelial Toxicity in a Niche-Specific Way.

The PKA pathway is a signaling pathway involved in virulence in . This mechanism can be activated via addition of glucose and activation involves at least two proteins, namely Cdc25 and Ras1. Both proteins are involved in specific virulence traits.