Psychomodulatory substances: New legislative framework for control of psychoactive substances in Czechia.

This article challenges drug prohibition advocated by UN conventions as the prevailing regulatory model for psychoactive substances, highlighting its ineffectiveness, harmfulness and outdated nature. At the same time, the conventions exclude some psychoactive substances from international regulation, leaving control to individual countries. Presenting an innovative approach, this article outlines an approach to the legal regulation of psychomodulatory substances (psychoactive substances with low health and societal risk) in non-medical contexts.

Biological activity of silver nanoparticles synthesized using viticultural waste.

This research paper presents a novel approach to the green synthesis of silver nanoparticles (AgNPs) using viticultural waste, allowing to obtain NP dispersions with distinct properties and morphologies (monodisperse and polydisperse AgNPs, referred to as mAgNPs and pAgNPs) and to compare their biological activities. Our synthesis method utilized the ethanolic extract of Vitis vinifera pruning residues, resulting in the production of mAgNPs and pAgNPs with average sizes of 12 ± 5 nm and 19 ± 14 nm, respectively. Both these AgNPs preparations demonstrated an exceptional stability in terms of size distribution, which was maintained for one year.

Bimetallic nanoparticle production using and waste extracts.

The utilization of waste materials for the synthesis of nanoparticles has gained significant attention due to its potential for waste valorization and contribution to circular economy. In this study, bimetallic nanoparticles were produced using extracts derived from and waste, focusing on their green synthesis and antimicrobial activity against Gram-negative bacteria, specifically several strains of . The canes and post-extraction waste from were processed using an ethanol extraction method.

Antibiofilm activity of silver nanoparticles biosynthesized using viticultural waste.

Green methods have become vital for sustainable development of the scientific and commercial sphere; however, they can bring new challenges, including the need for detailed characterization and elucidation of efficacy of their products. In this study, green method of silver nanoparticles (AgNPs) production was employed using an extract from grapevine canes. The aim of the study was to contribute to the knowledge about biosynthesized AgNPs by focusing on elucidation of their antifungal efficiency based on their size and/or hypothesized synergy with bioactive substances from Vitis vinifera cane extract.

Production and Characterization of Rhamnolipids Produced by DBM 3774: Response Surface Methodology Approach.

Rhamnolipids are extensively studied biosurfactants due to their potential in many industrial applications, eco-friendly production and properties. However, their availability for broader application is severely limited by their production costs, therefore the optimization of efficacy of their cultivation gains significance as well as the information regarding the physio-chemical properties of rhamnolipids resulting from various cultivation strategies. In this work, the bioprocess design focused on optimization of the rhamnolipid yield of DBM 3774 utilizing the response surface methodology (RSM).

Boswellic Acids as Effective Antibacterial Antibiofilm Agents.

Boswellic acids are biologically active pentacyclic terpenoid compounds derived from sp. plants. Extracts containing these acids have a number of positive effects on human health, especially in the treatment of inflammation, arthritis, or asthma.

Silver Nanoparticle Production Mediated by Cane Extract: Characterization and Antibacterial Activity Evaluation.

The ever-growing range of possible applications of nanoparticles requires their mass production. However, there are problems resulting from the prevalent methods of nanoparticle production; physico-chemical routes of nanoparticle synthesis are not very environmentally friendly nor cost-effective. Due to this, the scientific community started exploring new methods of nanoparticle assembly with the aid of biological agents.

Extract as an Antibiofilm Agent against spp.

The use of antibiotics or antifungals to control infections caused by pathogenic microorganisms is currently insufficiently effective because of their emerging resistance. Thanks to the ability of microorganisms to form a biofilm and thus increase their resistance to administered drugs even more, modern medicine faces the task of finding novel substances to combat infections caused by them. In this regard, the effects of essential oils or plant extracts are often studied.

Antimicrobial properties and applications of metal nanoparticles biosynthesized by green methods.

There is a growing interest in the potential and application of metal nanoparticles across many fields. A vast array of techniques for metal nanoparticle synthesis has been discovered; however, sustainability, cost-effectiveness, and environmental concerns favor the green biological approach, using various plant and microbial sources. This review describes the diversity in green methods for nanoparticle biosynthesis, antimicrobial properties of metal nanoparticles and their potential applications.

Rhamnolipids as a Tool for Eradication of Biofilm.

Microbial biofilms formed by pathogenic and antibiotic-resistant microorganisms represent a serious threat for public health in medicine and many industrial branches. Biofilms are involved in many persistent and chronic infections, the biofouling of water and food contamination. Therefore, current research is involved in the development of new treatment strategies.