Publications by authors named "Jana M Rocker"
A promising approach capitalizing on the specific and highly sensitive characteristics of the body's own immune system is demonstrated in the context of revealing pancreatic ductal adenocarcinoma cancer (PDAC). IgA from a local biofluid called gastrointestinal lavage fluid (GLF) is used to investigate glycan reactivity to show the potential of this approach. IgA antibody responses, just as with IgG, result in amplification of a small signal which aids in detecting changes from a healthy state.
View Article and Find Full Text PDFObjectives: There are currently no reliable, non-invasive screening tests for pancreatic ductal adenocarcinoma. The fluid secreted from the pancreatic ductal system ("pancreatic juice") has been well-studied as a potential source of cancer biomarkers. However, it is invasive to collect.
View Article and Find Full Text PDFArticle Synopsis
- Localized secretions, like gut lavage fluid, provide higher concentrations of organ-specific molecules compared to blood, making them superior for research.
- Gastrointestinal lavage is a simple and non-invasive procedure using solutions given before colonoscopies, resulting in a substantial amount of rectal effluent that can be studied.
- Despite the frequent collection of this effluent during colonoscopies, its potential for research on various diseases remains largely underutilized, sparking a need for comprehensive reviews and understanding of its collection and analysis methods.