Publications by authors named "Jana Luecht"
Int J Mol Sci
November 2024
Article Synopsis
- Congenital heart defects (CHDs) require surgery often involving cardiopulmonary bypass (CPB), which can result in significant post-operative complications due to an inflammatory response.
- A study examined how peri-operative serum samples from CHD patients affect macrophage inflammatory responses, finding that CPB activates the STAT3 signaling pathway but not NF-κB.
- Pre-treatment with Stattic, a STAT3 inhibitor, reduced various inflammatory mediators in macrophages, except for TNFα, indicating that CPB-induced inflammation is driven by cytokines like IL-6 and IL-8.
