Publications by authors named "Jana Kerlik"
Article Synopsis
- - The study aimed to estimate the prevalence of chronic Hepatitis C Virus (cHCV) infections in EU/EEA countries for the year 2019, using a method called multi-parameter evidence synthesis (MPES) to analyze data from various sources.
- - In 29 out of 30 EU/EEA countries, the overall cHCV prevalence was found to be 0.50%, with notably higher rates in the eastern EU/EEA (0.88%), and over a third of cases were linked to people who inject drugs (PWID).
- - The findings indicate that while cHCV prevalence is generally low, targeted efforts are needed, particularly in eastern regions and among PWID, to
Article Synopsis
- * Researchers conducted a study involving 40 European experts to identify and evaluate 59 potential drivers of TBE's emergence and rising incidence, categorizing them into eight domains.
- * The top drivers identified include changes in human behavior, eating habits, landscape alterations, environmental factors like humidity and temperature, and the presence of various tick species and wildlife reservoirs.
Article Synopsis
- Tick-borne encephalitis (TBE) is a vaccine-preventable disease affecting the central nervous system that was designated as notifiable in the EU/EEA in 2012.
- From 2012 to 2020, 19 EU/EEA countries reported nearly 30,000 cases, primarily in Czechia, Germany, and Lithuania, with the highest notification rates in Lithuania, Latvia, and Estonia.
- The number of TBE cases has shown a rising trend, indicating a need for close monitoring and potential adjustments to vaccination strategies to address geographical and population-specific risks.
Article Synopsis
- Viral infections from families such as Zika and Dengue pose significant challenges for diagnosis and tracking due to their short duration in the blood, vague symptoms, and laboratory cross-reactivity.
- In Central Europe, West Nile, Usutu, and tick-borne encephalitis viruses are the main endemic flaviviruses, causing serious neurological diseases and complicating blood and organ safety during transplants.
- The rise in co-circulation of these viruses highlights the inadequacy of current diagnostic methods, leading experts to advocate for the urgent adoption of advanced techniques like next-generation sequencing and urine screening in clinical practices.
There has been an increase in reported TBE cases in Europe since 2015, reaching a peak in some countries in 2020, highlighting the need for better management of TBE risk in Europe. TBE surveillance is currently limited, in part, due to varying diagnostic guidelines, access to testing, and awareness of TBE. Consequently, TBE prevalence is underestimated and vaccination recommendations inadequate.
View Article and Find Full Text PDFTick-borne encephalitis virus (TBEV) is transmitted mainly by tick bites, but humans can acquire infection through consuming unpasteurized milk from infected animals. Interhuman transmission of TBEV by breast milk has not been confirmed or ruled out. We report a case of probable transmission of TBEV from an unvaccinated mother to an infant through breast-feeding.
View Article and Find Full Text PDFBackground: Slovakia is well-known for tick-borne encephalitis alimentary (TBE) outbreaks in Europe for a long time. Since the first known and largest TBE alimentary outbreak in 1951 (at territory of Slovakia) until today, none of the European countries report a comparable number of TBE alimentary outbreaks with probable and laboratory confirmed food transmission factor as Slovakia.
Methods: We analyzed TBE outbreak confirmed cases reported in Slovakia from web-based Epidemiological Information System (EPIS) during the period 2007-2016.
The sympathoneural and the adrenomedullary systems are involved in regulation of immune processes. Their impairment has been suggested in patients with rheumatoid arthritis (RA). In this study, sympathetic response to orthostasis was evaluated in 22 RA females with <40 years of age and in 15 matched healthy controls.
View Article and Find Full Text PDFThe concept of relative adrenal insufficiency (RAI) has been originally introduced to describe a situation in which critically ill patients, without any prior risk or evidence for adrenal insufficiency, have total serum cortisol levels inadequate for the severity of patients' illness. The concept provided a framework for other disease states, in which higher than normal adrenal function could be expected, such as in chronic inflammation. An intense research in RAI field highlighted some new methodological aspects that significantly improved assessment of adrenal function in chronic illness.
View Article and Find Full Text PDFObjectives: To compare free plasma cortisol (FPC) with salivary and calculated cortisol.
Design And Methods: FPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women.
Results: FPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol.
Alterations in adrenal steroid production have been suggested in females with rheumatoid arthritis (RA). The aim of the present study was to assess adrenocortical function in RA females. We examined 11 female RA patients (RA: age 30 +/- 2 years, BMI 21.
View Article and Find Full Text PDFSympathoneural and adrenomedullary impairments have been suggested in patients with rheumatoid arthritis (RA). In the present study, sympathoneural and adrenomedullary responses to orthostasis were evaluated in eight female RA patients and in eight matched healthy controls. The testing consisted of sequence of stabilization period in supine position, legs-up position, orthostasis, and supine position.
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