Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients-A Controlled Clinical Trial.

Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem.

Methods: Obese (body mass index (BMI) ≥ 35 kg/m) and age-/sex-matched nonobese (18.5 kg/m ≥ BMI ≤ 30 kg/m) surgical patients received a short-term infusion of 1000-mg meropenem.

Afterdischarges elicited by cortical electric stimulation in humans: When do they occur and what do they mean?

Introduction: Afterdischarges (ADs) are a common and unwanted byproduct of direct cortical stimulation during invasive electroencephalography (EEG) recordings. Brief pulse stimulation (BPS) can sometimes terminate ADs. This study investigated AD characteristics and their relevance for emergence of stimulation seizures.