Publications by authors named "Jana Haller"
Background: Urine CXCL10 is a biomarker for renal allograft inflammation induced by rejection, urinary tract infection, or BK polyomavirus (BKPyV) replication. This study aimed to compare urine CXCL10 levels in different stages of BKPyV reactivation and to investigate urine CXCL10 as a biomarker for BKPyV replication.
Methods: We included 763 urine samples (235 patients) from an interventional, randomized trial obtained in the context of regular screening for urine CXCL10 levels.
Article Synopsis
- Delayed graft function (DGF) and donor-specific HLA-antibodies (DSA) are significant risk factors for kidney transplant rejection and reduced graft survival, yet their combined effects have not been extensively examined.
- In a study of 375 kidney transplant patients, DGF occurred in 37% and DSA in 23% of cases, showing DGF negatively impacts 5-year graft survival specifically in DSA-positive patients.
- The findings suggest that DGF in patients with DSA is linked to higher rates of subclinical rejection and graft loss, emphasizing the need to mitigate the combined risks of DGF and DSA for better transplant outcomes.