Early recruitment of PARP-dependent mA RNA methylation at DNA lesions is subsequently accompanied by active DNA demethylation.

RNA methylation, especially 6-methyladenosine (mA)-modified RNAs, plays a specific role in DNA damage response (DDR). Here, we also observe that RNA modified at 8-methyladenosine (mA) is recruited to UVA-damaged chromatin immediately after microirradiation. Interestingly, the level of mA RNA at genomic lesions was reduced after inhibition of histone deacetylases and DNA methyltransferases.