Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.

Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that express GABA. However, little is known about how sleep neuron function is determined and how sleep neurons change physiology and behavior systemically.

Automated analysis of sleep control via a single neuron active at sleep onset in C. elegans.

Longitudinal analyses are crucial for understanding long-term processes such as development and behavioral rhythms. For a complete understanding of such processes, both organism-level observations as well as single-cell observations are necessary. Sleep is an example for a long-term process that is under developmental control.

Reduced muscle contraction and a relaxed posture during sleep-like Lethargus.

Sleep is characterized by reduced muscle activity resulting in reduced movement and a typical posture compatible with relaxed muscles. Prior to each molt, C. elegans larvae go through a phase of behavioral quiescence called Lethargus.