Publications by authors named "Jan-Paul Herrmann"
Article Synopsis
- Urinary tract infections (UTIs) are commonly caused by bacteria, particularly Escherichia coli, with kidney infections (pyelonephritis) being severe and difficult to treat due to the unique kidney microenvironment.
- The study tested how factors like sodium chloride, urea, and pH levels affect the effectiveness of antibiotics (ertapenem, levofloxacin, and ceftriaxone) against E. coli strains in conditions mimicking the kidney.
- Findings showed that pH significantly affects levofloxacin's effectiveness, while sodium chloride and urea impact various strains differently, highlighting the need for more research on other antibiotics and kidney conditions for better treatment strategies.
Background: The intestinal microbiota fundamentally guides the development of a normal intestinal physiology, the education, and functioning of the mucosal immune system. The Citrobacter rodentium-carrier model in germ-free (GF) mice is suitable to study the influence of selected microbes on an otherwise blunted immune response in the absence of intestinal commensals.
Results: Here, we describe that colonization of adult carrier mice with 14 selected commensal microbes (OMM + MC) was sufficient to reestablish the host immune response to enteric pathogens; this conversion was facilitated by maturation and activation of the intestinal blood vessel system and the step- and timewise stimulation of innate and adaptive immunity.