Publications by authors named "Jan Witte"
Article Synopsis
- The study aimed to evaluate a personalized diagnostic pathway for patients with Chronic Obstructive Pulmonary Disease (COPD) or Asthma in a real-world outpatient setting.
- The results revealed that only 35% of patients attended all scheduled appointments after the pathway's implementation, with factors like logistical complexity and low socioeconomic status contributing to dropouts.
- Despite the challenges, the study showed a significant increase in the creation of personalized care plans and diagnostic documentation, indicating that holistic care planning can be effectively implemented, but improvements are needed to increase patient participation.
Article Synopsis
- * An 8-year follow-up study involved 15 of 78 patients from an initial trial, showing stable asthma control and lung function over time, despite weight regain in those who had surgery.
- * The study highlights that while some weight regain was noted, it had a clinically insignificant impact on asthma control and quality of life, underscoring bariatric surgery's effectiveness for obesity-related asthma.
Article Synopsis
- The study investigates the relationship between clustering analyses of COPD and the GOLD ABCD classification, focusing on whether new behavioral factors influence clustering outcomes.
- It found that while certain clusters aligned with the GOLD groups, the previously established clinical phenotypes couldn't be replicated in a new patient population.
- The inclusion of new variables like quality of life and daily activities led to the formation of distinct clusters, suggesting that using cluster analysis for identifying COPD phenotypes may not effectively guide individual treatment strategies.
Article Synopsis
- Asthma patients with obesity face higher disease burdens and often experience low effectiveness from inhaled corticosteroids (ICS), which can also lead to negative side effects like weight gain and diabetes.
- The study, known as the STOP trial, aims to determine if ICS can be safely withdrawn in individuals with T2-low asthma and obesity while maintaining controlled asthma symptoms.
- Participants will be randomly assigned to either a control group receiving ICS or an intervention group that will taper off ICS, followed by a crossover to assess long-term metabolic effects of ICS withdrawal.
Study Objective: The study objective is to determine whether extraglottic airway devices (EADs) with or without mask aperture bars (MABs) result in similar anatomical positions in patients undergoing surgery.
Design: Prospective, randomized, crossover comparison of four extraglottic airway devices.
Setting: Operating theatre at a large teaching hospital.
The sacroiliac joint accounts for approximately 16% to 30% of cases of chronic mechanical low back pain. Pain originating in the sacroiliac joint is predominantly perceived in the gluteal region, although pain is often referred into the lower and upper lumbar region, groin, abdomen, and/ or lower limb(s). Because sacroiliac joint pain is difficult to distinguish from other forms of low back pain based on history, different provocative maneuvers have been advocated.
View Article and Find Full Text PDFBackground: We evaluated the efficacy of resistive-heating or forced-air warming versus no prewarming, applied before induction of anesthesia for prevention of hypothermia.
Methods: Twenty-seven patients scheduled for laparoscopic colorectal surgery were randomized into 1 of 3 groups: no prewarming; 30 minutes of prewarming with a carbon fiber total body cover at 42 degrees C; or 30 minutes of preoperative forced-air warming at 42 degrees C. The forced-air warming cover excluded the shoulders, ankles, and feet.
Postoperative residual paralysis is an important complication of the use of neuromuscular blocking drugs. In this prospective study, the incidence of residual paralysis detected as a train-of-four response <90% was less frequent in surgical outpatients (38%) than inpatients (47%) (P = 0.001).
View Article and Find Full Text PDFIn recent years it has become clear that multiple sclerosis (MS) patients benefit from physical exercise as performed in aerobic training but little is known about the effect on functional domains and physiological factors mediating these effects. We studied immunological, endocrine and neurotrophic factors as well as coordinative function and quality of life during an 8-week aerobic bicycle training in a waitlist control design. In the immune-endocrine study (1) 28 patients were included, the coordinative extension study (2) included 39 patients.
View Article and Find Full Text PDFUnlabelled: Because an oral formulation of midazolam is not approved in certain countries, we evaluated oral alprazolam as an alternative. Forty-five outpatients scheduled for gynecological laparoscopic surgery participated in a double-blinded study to compare the effectiveness and side effects of oral alprazolam 0.5 mg with midazolam 7.
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