Publications by authors named "Jan Vilimovsky"
Purpose: Despite advancements in radiation techniques, concerns persist regarding the adverse effects of radiation therapy, particularly cardiotoxicity or radiation-induced heart disease. Recently, arrhythmogenic toxicity has come to the forefront-the impact of radiation therapy on the cardiac conduction system. Our objective was to conduct a dosimetric study and subsequently investigate the feasibility of optimizing the sinoatrial (SA) and atrioventricular (AV) nodes as organs at risk (OARs) in proton radiation therapy for non-small cell lung cancer with N3 disease.
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- - Boron may improve the effectiveness of proton beam therapy in cancer treatment by enhancing cell damage in the targeted Bragg peak region through a specific nuclear reaction, although some studies have questioned this claim.
- - Experiments with prostate cancer and glioblastoma cells using 190 MeV proton beams showed that boron (from sodium mercaptododecaborate) significantly increased cell killing, especially at low concentrations and in the Bragg peak area.
- - The beneficial effects of boron occur through rare proton-boron reactions generating alpha particles, which lead to enhanced cell death, and this response seems to be amplified through interactions between cells, highlighting its potential for clinical use in treating certain tumors.