Publications by authors named "Jan Thomassen"
Article Synopsis
- The study looked at how a bacteria called Pa affects lung disease in people with cystic fibrosis (CF) by causing inflammation and scarring.
- Researchers measured different substances in the spit of CF patients to see how Pa infection changed things like inflammation and lung function.
- They found that Pa infection led to an imbalance in certain proteins, increased inflammation, and poorer lung function, suggesting that treating this inflammation could help CF patients in the future.
Background: Malignant intrinsic brain tumors are a hazardous disease with limited life expectancy despite intensive research in new targeted treatment options. Lately, proteasome inhibitors have been identified as potent agents causing death in glioma cell lines. It is the aim of the present study to identify proteasomal activity in the CSF of patients suffering from malignant brain tumors.
View Article and Find Full Text PDFObjective: To investigate the effect of Lumacaftor/Ivacaftor on glucose metabolism and insulin secretion in patients with cystic fibrosis (CF) (Phe508del/Phe508del).
Methods: A standard oral glucose tolerance test (OGTT) and an intravenous glucose tolerance test (IVGTT) were performed to investigate glucose metabolism and insulin secretion before and after 6-8weeks of treatment with Lumacaftor/Ivacaftor in 5 Phe508del-homozygous CF patients. The area under the curve (AUC) for glucose and insulin levels was calculated using the trapezoidal approximation.
Alterations of the intracellular ubiquitin-proteasome pathway are found in neurodegenerative and inflammatory disorders of the central nervous system, as well as in its malignancies. Inhibitory substrates of the proteasomes represent promising approaches to control autoimmune inflammations and induction of apoptosis in cancer cells. Extracellular circulating proteasomes are positively correlated to outcome prognosis in hematogenic neoplasias and the outcome in critically ill patients.
View Article and Find Full Text PDFA tutorial platform suitable for surgical simulator training (SimMentor).
Stud Health Technol Inform
November 2004
Background: The introduction of simulators in surgical training entails the need to develop pedagogic platforms adapted to the potentials and limitations provided by the information technology. As a solution to the technical challenges in treating all possible interaction events and to obtain a suitable pedagogic approach, we have developed a pedagogic platform for surgical training, SimMentor.
Methods: In SimMentor the procedure to be practiced is divided into a number of natural phases.