Publications by authors named "Jan Thomas Kielstein"
Background: A large variety of imaging techniques is an integral part of modern medicine. Introducing radiological imaging techniques into the dissection course serves as a basis for improved learning of anatomy and multidisciplinary learning in pre-clinical medical education.
Methods: Four different imaging techniques (ultrasound, radiography, computed tomography, and magnetic resonance imaging) were performed in embalmed human body donors to analyse possibilities and limitations of the respective techniques in this peculiar setting.
Article Synopsis
- Atypical haemolytic-uremic syndrome (aHUS) is a serious condition linked to problems with complement regulation, but the exact connection between complement issues and blood clot formation in aHUS is still unclear.
- Researchers studied kidney tissues from patients with aHUS and controls, measuring the expression of genes related to blood clot formation and breakdown.
- Findings showed that aHUS patients had higher levels of PAI-1 (an antifibrinolytic factor) and thrombomodulin, while levels of tPA (a profibrinolytic factor) were lower, suggesting impaired blood clot breakdown may be key to the disease's progression.
Aim: Increased levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been observed in patients with cardiovascular risk factors and atherosclerosis and in patients with a history of stroke. The role of ADMA and its analogue symmetric dimethylarginine (SDMA) in acute ischemic stroke is yet unclear. We hypothesized that plasma dimethylarginine levels increase in the hyper-acute phase after ischemic stroke and that their time course is related to stroke outcome.
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