Publications by authors named "Jan Thomann"
Article Synopsis
- - Classic psychedelics like mescaline have renewed interest in therapy, but there's limited modern data on its effects and mechanisms of action in humans due to a lack of comprehensive studies.
- - In a study with 16 healthy participants, mescaline was administered in varying doses (100-800 mg) to assess subjective and autonomic effects, showing that higher doses produced stronger effects, increased heart rate, and elevated blood pressure without notable differences between doses above 100 mg.
- - The combination of mescaline and the 5-HT receptor antagonist ketanserin decreased and shortened the effects of the highest dose, suggesting the acute effects of mescaline are mainly mediated by these serotonin receptors, while nausea was a common
Article Synopsis
- Psilocybin is quickly converted to psilocin, which produces psychedelic effects by targeting the 5-HT receptor, and its metabolism involves converting psilocin to other compounds like 4-HIAA and 4-HTP.
- The study analyzed metabolic processes using human liver microsomes and various enzymes, revealing that male C57BL/6J mice and human samples showed different metabolic rates and pathways for psilocin.
- Key enzymes such as MAO-A, CYP2D6, and CYP3A4 play roles in psilocin metabolism, with the identification of new metabolites like norpsilocin and oxidized psilocin, which could inform future research on drug interactions and ps
Derivatization-free determination of chiral plasma pharmacokinetics of MDMA and its enantiomers.
J Chromatogr B Analyt Technol Biomed Life Sci
May 2024
3,4-Methylenedioxymethamphetamine (MDMA) is an entactogen with therapeutic potential. The two enantiomers of MDMA differ regarding their pharmacokinetics and pharmacodynamics but the chiral pharmacology of MDMA needs further study in clinical trials. Here, an achiral and an enantioselective high performance liquid chromatography-tandem mass spectrometry method for the quantification of MDMA and its psychoactive phase I metabolite 3,4-methylenedioxyamphetamine (MDA) in human plasma were developed and validated.
View Article and Find Full Text PDFDevelopment and validation of an LC-MS/MS method for quantifying diamorphine and its major metabolites 6-monoacetylmorphine, morphine, morphine-3-glucuronide, and morphine-6-glucuronide in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
April 2024
Diamorphine, commonly known as heroin, is a semi-synthetic opioid analgesic. In the context of heroin-assisted treatment for opioid-dependent patients, diamorphine is mostly administered intravenously. However, recent attention has shifted towards intranasal administration as a better-tolerated alternative to the intravenous route.
View Article and Find Full Text PDFMescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects of these substances is lacking. The main goal of the present study was to investigate potential pharmacological, physiological and phenomenological differences at psychoactive-equivalent doses of mescaline, LSD, and psilocybin.
View Article and Find Full Text PDFMescaline is a psychedelic phenethylamine found in different species of cacti. Currently, mescaline's acute subjective effects and pharmacokinetics are investigated in several modern clinical studies. Therefore, we developed a bioanalytical method for the rapid quantification of mescaline and its metabolites in human plasma.
View Article and Find Full Text PDFPyrovalerone cathinones are potent psychoactive substances that possess a pyrrolidine moiety. Pyrovalerone-type novel psychoactive substances (NPS) are continuously detected but their pharmacology and toxicology are largely unknown. We assessed several pyrovalerone and related cathinone derivatives at the human norepinephrine (NET), dopamine (DAT), and serotonin (SERT) uptake transporters using HEK293 cells overexpressing each respective transporter.
View Article and Find Full Text PDFAim: To examined the effects of stochastic resonance whole-body vibration training on musculoskeletal pain in young healthy individuals.
Methods: Participants were 43 undergraduate students of a Swiss University. The study was designed as a randomized controlled trial (RCT) with randomized group allocation.