Publications by authors named "Jan Spychala"
Article Synopsis
- The study investigates four olivacine derivatives to determine which has the strongest antitumor activity against cancer cell lines CCRF/CEM and MCF-7.
- The testing included several methods such as comet assays and molecular docking to evaluate how each compound interacts with DNA and topoisomerase II.
- Among the compounds, one (9-methoxy-5,6-dimethyl-1-({[1-hydroxy-2-(hydroxymethyl)butan-2-yl]amino}methyl)-6-pyrido[4,3-]carbazole) showed the best potential as an anticancer drug due to its high affinity for topoisomerase II and minimal genotoxic effects.
The co-ordination chemistry of some new oxamides towards Cu(II) ions was studied using various techniques: potentiometry, voltammetry, spectroscopy (UV-Vis, CD and EPR) and ESI-MS spectrometry. All tested compounds chelate the copper(II) ions with formation of 1:1 and 1:2 (metal-to-ligand ratio) complexes. The Cu(II) ions are bound by 1N, 2N or 3N nitrogen donor systems.
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