Effects of lifestyle intervention on IGF-1, IGFBP-3, and insulin resistance in children with obesity with or without metabolic-associated fatty liver disease.

Obesity is a strong predictor for metabolic associated fatty liver disease (MAFLD), which has been associated with decreased insulin like growth factor 1 (IGF-1). In obesity, weight loss increases growth hormone secretion, but this is not unequivocally associated with increases in serum IGF-1 and IGF binding protein-3 (IGFBP-3). We studied the changes in the IGF axis in relation to weight loss and improvement in insulin resistance in children with or without MALFD after 10 weeks of lifestyle intervention at a weight loss camp (WLC).

Cryoablation of Renal Angiomyolipoma: An Evaluation of Safety and Efficacy.

Background: Small series have reported that cryoablation (CA) is a safe and feasible minimally invasive nephron-sparing alternative for the treatment of renal angiomyolipomas (renal AMLs). The aim of the present study was to investigate the safety and efficacy of CA in patients with renal AML.

Materials And Methods: A retrospective review of 19 renal AML lesions treated with CA at Aarhus University Hospital, Denmark, over a 5-year period.

Effect of a 10-week weight loss camp on fatty liver disease and insulin sensitivity in obese Danish children.

Background And Objective: Childhood nonalcoholic fatty liver disease (NAFLD) associated with insulin resistance and obesity is a growing problem and increases the risk of cirrhosis, type 2 diabetes mellitus, and cardiovascular complications. We examined the effects of a 10-week "weight loss camp" residency in obese children on the prevalence and degree of NAFLD and insulin sensitivity with 12-month follow-up.

Methods: At the camp, 117 obese white children (body mass index 28.

Single-centre review of radiologically guided percutaneous nephrostomy using "mixed" technique: success and complication rates.

Aim: A review of complication and success rates of the "mixed" technique in percutaneous nephrostomy using both the Seldinger and one-step techniques in dilated and non-dilated systems.

Materials And Methods: We retrospectively analysed 500 percutaneous nephrostomies in dilated an non-dilated systems in 353 patients from 2006 to 2007 (208 males (range 19-95 years), 127 females (range 27-91 years) and 21 children (range 3 months-16 years: 6 females, 15 males)). Percutaneous nephrostomy was considered successful if catheter was placed in renal pelvis and drained urine spontaneously.

Prostate cancer: to scan or not to scan for lymph node involvement?

Objective: When diagnosing lymph node involvement in prostate cancer (PC), the available imaging techniques are considered to be of doubtful value but are still in common use in many institutions because of a lack of better alternatives. To help us choose between methods while we wait for improvements in technologies, we evaluated the performance of ultrasonography (US), CT and MRI.

Material And Methods: We reviewed the records of all PC patients who were potential candidates for a surgical staging procedure prior to treatment with intent to cure at Skejby Sygehus, Denmark between 1996 and 2004.