Publications by authors named "Jan S Schouten"
Purpose: The aim of this study is to generate reference values for anterior chamber morphometrics to facilitate the interpretation of anterior chamber images acquired with swept-source optical coherence tomography (SS-OCT) in a Caucasian population.
Materials And Methods: Non-glaucomatous Caucasian subjects, who were newly referred to the outpatient department of the University Eye Clinic Maastricht UMC+, were asked to undergo anterior segment assessment with SS-OCT imaging prior to routine eye examination (including visual acuity and refractive error measurements, Goldmann applanation tonometry, slit lamp examination and funduscopy).
Results: A total of 647 Caucasian subjects, aged 40-80 years, were included.
Background: Describing the natural course of neovascular age-related macular degeneration (nAMD) is essential in discussing prognosis and treatment options with patients and to support cost-effectiveness studies.
Methods: First, we performed a literature search in PubMed, Embase, and Cochrane. We included randomized clinical trials and prospective observational studies reporting visual acuity (VA) in non-treated patients, 24 studies in total.
Treatment of cystoid macular edema after cataract surgery.
J Cataract Refract Surg
February 2017
The purpose of this review was to determine the optimum pharmacologic treatment for cystoid macular edema (CME) after cataract surgery in nondiabetic and diabetic patients. The Cochrane Library, Medline, and Embase databases were searched, and all randomized controlled trials (RCTs) that compared at least 2 pharmacologic strategies for CME after cataract surgery were included. Studies were excluded if preoperative CME or other risk factors for developing CME postoperatively were present.
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- * Comprehensive eye examinations and next-generation sequencing (NGS) identified specific mutations in the CHM gene, which were confirmed in both families, with asymptomatic family members identified as carriers.
- * The findings highlight how these genetic mutations impact retinal health, leading to abnormalities due to diminished production of Rab escort protein-1 (REP-1), which is crucial for retinal function.
Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease. This can be partly explained by large-artery dysfunction, which already occurs in prediabetes ("ticking clock hypothesis"). Whether a similar phenomenon also applies to microvascular dysfunction is not known.
View Article and Find Full Text PDFPurpose: To determine whether there is a level of visual acuity (VA) in neovascular age-related macular degeneration (nAMD) above which the correlation of VA with disease-related quality of life (QoL) is significantly greater than below this level.
Design: An observational, cross-sectional study.
Participants: A total of 184 patients with nAMD aged at least 50 years were included in the study.
Visual Complaints and Eye Problems in Orchestral Musicians.
Med Probl Perform Art
September 2016
Objective: To study visual complaints and eye diseases among professional and amateur orchestral musicians in the Netherlands.
Methods: In this observational study, members from professional and amateur symphony or wind orchestras were asked to complete a questionnaire collecting demographic data, musical, medical, and family history, and data on present visual complaints and/or eye diseases. Questions about playing in the orchestra were also asked.
Purpose: Glaucoma patients are still at risk of becoming blind. It is of clinical significance to determine the risk of blindness and its causes to prevent its occurrence. This systematic review estimates the number of treated glaucoma patients with end-of-life visual impairment (VI) and blindness and the factors that are associated with this.
View Article and Find Full Text PDFPurpose: To evaluate the optimum medical strategy to prevent cystoid macular edema (CME) after cataract surgery.
Design: Systematic review and meta-analysis.
Methods: setting: Cochrane, MEDLINE, and EMBASE databases were searched to identify eligible randomized controlled trials (RCTs).
Optical coherence tomography (OCT) of the retina and around the optic nerve head and corneal confocal microscopy (CCM) are non-invasive and repeatable techniques that can quantify ocular neurodegenerative changes in individuals with diabetes. We systematically reviewed studies of ocular neurodegenerative changes in adults with type 1 or type 2 diabetes and noted changes in the retina, the optic nerve head, and the cornea. Of the 30 studies that met our inclusion criteria, 14 used OCT and 16 used CCM to assess ocular neurodegenerative changes.
View Article and Find Full Text PDFAim: To assess the functional aspects of cone mosaic and correlate cone packing with retinal sensitivity utilizing microperimetry in emmetropes at different eccentricities.
Methods: Twenty-four healthy volunteers underwent microperimetry (MAIA Centervue, Italy) and assessment of photoreceptors using adaptive optics retinal camera, rtx1 (Imagine Eyes, Orsay, France), at 2 and 3 degrees from the foveal centre in 4 quadrants: superior, inferior, temporal, and nasal. Data was analyzed using SPSS version 17 (IBM).
Aim: To assess the variations in cone mosaic in myopia and its correlation with axial length (AL).
Subjects And Methods: Twenty-five healthy myopic volunteers underwent assessment of photoreceptors using adaptive optics retinal camera at 2° and 3° from the foveal center in four quadrants superior, inferior, temporal and nasal. Data was analyzed using SPSS version 17 (IBM).
Purpose: To develop a prediction model for glaucomatous visual field progression using easily accessible baseline clinical data.
Patients And Methods: We collected baseline data of 613 consecutive patients with open-angle glaucoma from 2001 to 2003. The rate of visual field progression was calculated using the Visual Field Index (VFI) of routine follow-up examinations until 2010.
Background: Age-related macular degeneration (AMD) is a blinding disease placing considerable burden on society due to blindness-associated costs. Intravitreal anti-vascular endothelial growth factors (anti-VEGFs) are effective in reducing the incidence of blindness, but at potentially high costs, depending on the cost of the drug used. Aflibercept has been introduced as an anti-VEGF equally effective to ranibizumab, but less costly.
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- Diabetic macular edema (DME) is a serious complication of diabetic retinopathy, currently managed through a trial and error method involving medications like antivascular endothelial growth factor (VEGF) or steroids, but using patients' genetic profiles could lead to more personalized treatments.
- The study involved analyzing blood samples from 20 DME patients divided into four groups: nondiabetic, treatment naive, treatment responders, and treatment nonresponders, utilizing RNA extraction, microarray technology, and gene classification to identify relevant pathways.
- Results showed 5 genes were upregulated and 105 were downregulated across groups, with no common upregulated genes between responders and nonresponders, suggesting distinct genetic behaviors that can inform treatment strategies for
Purpose: To investigate the long-term health and economic consequences of direct treatment initiation in ocular hypertension patients.
Methods: A cost-effectiveness analysis with a societal perspective and a lifelong horizon was performed. The primary outcomes were the incremental quality-adjusted life years (QALYs) and costs of direct pressure-lowering treatment for ocular hypertension, compared to a strategy where treatment is postponed until conversion to glaucoma has been observed.
Purpose: To estimate the risk of blindness in patients with ocular hypertension (OHT) using an appropriate model and current empirical data.
Design: A Markov model with data from a systematic literature review.
Methods: A Markov model with 3 health states was built: OHT, primary open-angle glaucoma (POAG), and unilateral blindness.
Purpose: To assess the prevalence of end-of-life visual impairment in patients followed for glaucoma.
Methods: Data of 122 patients followed for glaucoma who had died between July 2008 and July 2010 and who had visited the ophthalmology outpatient department of a large non-academic Dutch hospital were collected from the medical files. Sixty-one patients had open-angle glaucoma (OAG), and 61 patients were suspect for glaucoma or had ocular hypertension (OHT).
Purpose: To examine which prognostic factors are associated with glaucomatous visual field progression.
Design: Knowledge of prognostic factors helps clinicians to select patients at risk of glaucomatous visual field progression and intensify their treatment.
Methods: By consulting relevant databases, we identified 2733 articles published up to September 2010, of which 85 articles investigating prognostic factors for visual field progression in patients with open-angle glaucoma (OAG) were eligible.
Purpose: To study the effect of patient education and the TravAlert(®) -Eyot(®) drop guider on intraocular pressure (IOP) and adherence in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT) monitored with the TravAlert(®) dosing aid.
Methods: Multicentre, randomized, controlled clinical trial among 18 Dutch hospitals. Patients were randomized to one of the four study arms: (1) use of the dosing aid, (2) use of the dosing aid with the drop guider, (3) use of the dosing aid together with patient education or (4) use of the dosing aid and drop guider together with patient education.
Background: Orientation and mobility (O&M) training in using an identification (ID) cane is provided to partially-sighted older adults to facilitate independent functioning and participation in the community. Recently, a protocolised standardised O&M-training in the use of the ID cane was developed in The Netherlands. The purpose of this study is to assess the usefulness and acceptability of both the standardised training and the regular training for participants and O&M-trainers in a randomised controlled trial (NCT00946062).
View Article and Find Full Text PDFPurpose: To present a new epidemiological method relying on randomized controlled clinical trial (RCT) data to assess whether a treatment was effective, aiding in the decision to continue or stop the treatment in clinical patients.
Methods: A cutoff point is calculated in the change of a continuous outcome for which a proportion of treated patients clearly achieved a change better than this cutoff point as a result of the treatment. This cutoff point can then be applied to individual patients during routine therapy.
Purpose: To evaluate cost-effectiveness of penetrating keratoplasty (PK), femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS-DSEK), and Descemet stripping automated endothelial keratoplasty (DSAEK).
Design: Cost-effectiveness analysis based on data from a randomized multicenter clinical trial and a noncomparative prospective study.
Methods: Data of 118 patients with corneal endothelial dysfunction were analyzed in the economic evaluation.