Publications by authors named "Jan Marcusson"

Objective: To explore frail older persons' perceptions of the future and the end of life.

Design: Qualitative content analysis of individual semi-structured interviews.

Setting: Nine primary health care centres in both small and middle-sized municipalities in Sweden that participated in the intervention project Proactive healthcare for frail elderly persons.

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Most adverse events in health care are related to medication management and they are almost always preventable. Increased knowledge of patient safety related to medication management in home health care is an urgent issue to provide safe care for all patients regardless of where the health care takes place. This study explored patient safety within medication management in municipal home health care.

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Objectives: To estimate the cost-effectiveness of a pragmatic trial of comprehensive geriatric assessment adapted to primary care, compared with care as usual.

Design: Within-trial cost-effectiveness study of a prospective controlled multicenter trial.

Setting And Participants: Nineteen primary care practices in Sweden.

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Article Synopsis
  • The study investigates the prevalence of amyloid aggregation, a key feature of Alzheimer's disease, in individuals with varying cognitive statuses, including those with normal cognition and who have clinical AD dementia.
  • It analyzes how factors like age, sex, educational background, and the method of detecting amyloid (CSF or PET scans) influence the prevalence estimates.
  • Data were collected from 85 study cohorts between 2013 and 2020, using a systematic approach to categorize amyloid measurements as normal or abnormal.
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Purpose: Despite evidence that older persons want to be involved in care, little is known about how frail older people with significant care needs living at home experience participation in care provided by different stakeholders. This study investigates the experiences of participation in care by older people following their involvement in an intervention of a health care model called Focused Primary care (FPC).

Methods: Individual semi-structured interviews were conducted with 20 older persons in five municipalities in Sweden.

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Background: The healthcare system needs effective strategies to identify the most vulnerable group of older patients, assess their needs and plan their care proactively. To evaluate the effectiveness of comprehensive geriatric assessment (CGA) of older adults with a high risk of hospitalisation we conducted a prospective, pragmatic, matched-control multicentre trial at 19 primary care practices in Sweden.

Methods: We identified 1604 individuals aged 75 years and older using a new, validated algorithm that calculates a risk score for hospitalisation from electronic medical records.

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Comprehensive geriatric assessment (CGA) is recommended for the management of frailty. Little is known about professionals' experiences of CGA; therefore we wanted to investigate the experiences of staff in primary care using a new CGA tool: the Primary care Assessment Tool for Elderly (PASTEL). Focus group interviews.

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Background: The healthcare for older adults is insufficient in many countries, not designed to meet their needs and is often described as disorganized and reactive. Prediction of older persons at risk of admission to hospital may be one important way for the future healthcare system to act proactively when meeting increasing needs for care. Therefore, we wanted to develop and test a clinically useful model for predicting hospital admissions of older persons based on routine healthcare data.

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Objectives: Both morbidity and mortality are elevated for individuals with subsyndromal depression (SSD) compared to non-depression (ND) in those of younger ages, but scientific studies are scarce for very old individuals. The aim of this study was therefore to compare the morbidity and mortality in very old individuals with SSD and ND.

Design And Setting: An 8-year prospective population-based study was undertaken on 85-year-old individuals in Sweden.

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Background: There are several cognitive assessment tools used in primary care, e.g., the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment.

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Normative data for evaluating cognitive function in the oldest old, aged 85 years and above, are currently sparse. The normative values used in clinical practice are often derived from younger old persons, from small sample sizes or from broad age spans (e.g.

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Background/objectives: Dementia and cognitive impairment are common in nursing homes. Few studies have studied the impact of unnoted cognitive impairment on medical care. This study aimed to estimate the prevalence of diagnostic failure of cognitive impairment in a sample of Swedish nursing home residents and to analyze whether diagnostic failure was associated with impaired medical care.

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Introduction: The provision of healthcare services is not dedicated to promoting maintenance of function and does not target frail older persons at high risk of the main causes of morbidity and mortality. The aim of this study is to evaluate the effects of a proactive medical and social intervention in comparison with conventional care on a group of persons aged 75 and older selected by statistical prediction.

Methods And Analysis: In a pragmatic multicentre primary care setting (n=1600), a prediction model to find elderly (75+) persons at high risk of complex medical care or hospitalisation is used, followed by proactive medical and social care, in comparison with usual care.

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Background/objectives: Normative Mini-mental state examination (MMSE) reference values in elderly are scarce. Therefore, the aim is to present normative MMSE values for 85-93 year olds.

Design: A longitudinal age cohort study.

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Objectives: This study aimed to compare, over a 5-year period, the prospective direct healthcare costs and service utilization of persons with subsyndromal depression (SSD) and non-depressive persons (ND), in a population of very old persons. A second aim was to develop a model that predicts direct healthcare costs in very old persons with SSD.

Design And Setting: A prospective population-based study was undertaken on 85-year-old persons in Sweden.

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Article Synopsis
  • - The study examined the prevalence of the APOE ε4 genetic risk factor for Alzheimer's disease (AD) in a group of 3451 individuals with confirmed amyloid β (Aβ) pathology, which had not been consistently used in earlier research.
  • - Results showed that APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal individuals, with a notable decrease in prevalence as age increased among those who were cognitively normal or had mild cognitive impairment.
  • - The findings indicated that the prevalence of APOE ε4 was higher than previously reported, underscoring significant differences in disease presentation based on age and geographic location, particularly being highest
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Article Synopsis
  • The study explores the link between amyloid-β aggregation, an early indicator of Alzheimer's disease, and cognitive functioning in individuals without dementia to improve our understanding of Alzheimer's progression and prevention strategies.
  • It included a large sample of 7,041 participants, split between those with normal cognition and those with mild cognitive impairment, assessing cognitive performance and amyloid levels using various diagnostic tools.
  • Findings revealed that amyloid positivity was significantly associated with lower memory scores, particularly in individuals over the age of 70, indicating a potential cognitive decline related to amyloid aggregation in older adults.
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Article Synopsis
  • Reference intervals are important for assessing disease but often exclude the elderly, so this study aimed to evaluate certain blood analytes in elderly individuals with varying health statuses.
  • The study included 569 nursing home residents over 80 years old, divided into frail, moderately healthy, and healthy cohorts, with blood samples analyzed for albumin, ALT, AST, creatinine, and γ-GT levels.
  • Results showed that various factors like daily activities, gender, and health conditions significantly influenced the levels of these analytes, highlighting the complexity of interpreting lab results for elderly patients.
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Ability to predict and prevent incipient functional decline in older adults may help prolong independence. Cognition is related to everyday function and easily administered, sensitive cognitive tests may help identify at-risk individuals. Factors like depressive symptoms and self-rated health are also associated with functional ability and may be as important as cognition.

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Background: According to the Swedish National Board of Health and Welfare, structured assessment of function and activity has high priority when evaluating suspected cognitive impairment or dementia.

Aim/objectives: The aim was to develop and psychometrically test an instrument to measure the ability to perform activities of daily living tasks in patients with suspected cognitive impairment.

Material And Methods: The Cognitive Impairment in Daily Life (CID) instrument (for self-reported and informant-based assessments) has been developed in several phases.

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Objective: To investigate factors associated with subsyndromal depression (SSD) in very old persons, and to develop a model for prediction of SSD among very old persons.

Methods: A cross-sectional, population-based study was undertaken on 85-year-old persons in Sweden. Data were collected from a postal questionnaire, assessments in the participants' homes and at reception visits.

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Article Synopsis
  • The study highlights that the buildup of amyloid-β, a marker linked to Alzheimer’s disease, begins long before dementia is diagnosed, emphasizing the need for understanding its prevalence in cognitively healthy individuals and pre-dementia stages for future prevention efforts.
  • Researchers conducted a meta-analysis using data from over 10,000 participants to estimate amyloid pathology prevalence across various cognitive states (normal cognition, subjective cognitive impairment, and mild cognitive impairment) based on factors such as age and genetics.
  • Findings indicated that amyloid pathology prevalence increases significantly with age, reaching as high as 71% in individuals with mild cognitive impairment, and that carriers of the APOE-ε4 gene have notably higher prevalence
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Background: The aim of this study was to explore experiences of cognitive impairment, its consequences in everyday life and need for support in people with mild cognitive impairment (MCI) or mild dementia and their relatives.

Methods: A qualitative approach with an explorative design with interviews was chosen. The participants included five people with MCI and eight people with mild dementia and their relatives.

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Background: Mild traumatic brain injury (TBI) or concussion is common in many sports. Today, neuropsychological evaluation is recommended in the monitoring of a concussion and in return-to-play considerations. To investigate the sensitivity of neuropsychological assessment, we tested amateur boxers post bout and compared with controls.

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Background. Diagnostic evaluations of dementia are often performed in primary health care (PHC). Cognitive evaluation requires validated instruments.

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