Colchicine and diabetes in patients with chronic coronary artery disease: insights from the LoDoCo2 randomized controlled trial.

Introduction: Despite optimal treatment, patients with chronic coronary artery disease (CAD) and diabetes mellitus (DM) are at high risk of cardiovascular events, emphasizing the need for new treatment options. The Low-Dose Colchicine 2 (LoDoCo2) trial demonstrated that colchicine reduces cardiovascular risk in patients with chronic CAD. This analysis determines the efficacy of colchicine in patients with chronic CAD and DM as well as the effect of colchicine on the development of new-onset type 2 diabetes mellitus (T2DM).

Dynamic aspects of ventricular interaction during exercise in HFpEF and in pre-capillary pulmonary hypertension.

Aims: The contribution of adverse ventricular interdependence remains undervalued in heart failure or pulmonary vascular disease, and not much is known about its dynamic nature during exercise and respiration. In this study, we evaluated ventricular interaction during exercise in patients with heart failure with preserved ejection fraction (HFpEF) and patients with chronic thromboembolic pulmonary hypertension (CTEPH) as compared with healthy controls.

Methods And Results: Forty-six subjects (10 controls, 19 CTEPH patients, and 17 HFpEF patients) underwent cardiac magnetic resonance imaging during exercise.

Influence of the exchange and correlation functional on the structure of amorphous InSb and In3SbTe2 compounds.

We have investigated the structural, vibrational, and electronic properties of the amorphous phase of InSb and In3SbTe2 compounds of interest for applications in phase change non-volatile memories. Models of the amorphous phase have been generated by quenching from the melt by molecular dynamics simulations based on density functional theory. In particular, we have studied the dependence of the structural properties on the choice of the exchange-correlation functional.

Endoscopic ultrasound fine needle aspiration in the diagnosis of lymphoma.

In recent years, endoscopic ultrasound techniques with Fine Needle Aspiration (FNA) have become an increasingly used diagnostic aid in the differentiation of mediastinal lymphadenopathy. Endobronchial ultrasound (EBUS) and endoesophageal ultrasound (EUS) are now available for clinicians to reach mediastinal and paramediastinal masses using a minimally invasive approach. These techniques are an established component for diagnosing and staging lung cancer and their benefit in the diagnosis of lymphoma's has been highlighted in a number of case studies.

EUS-FNA of enlarged necrotic lymph nodes may cause infectious mediastinitis.

Transesophageal endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is a minimally invasive technique to investigate the mediastinum. Although EUS-FNA can be considered in general as a safe technique, complications do occur. We here report an infectious complication of EUS-FNA that occurred after puncture of a large malignant necrotic mediastinal lymph node.

Effective kinetic phase diagrams.

The composition of a solid solution that is growing at conditions well away from equilibrium is not prescribed by equilibrium thermodynamics, but is determined kinetically. It depends both on the surface kinetics and on the transport of mass and heat to and away from the solidification front. In previous work, we have formulated a model for the kinetic or nonequilibrium segregation taking place at the solidification front enabling the construction of kinetic phase diagrams, which gives the growth composition of a solid solution as a function of the liquid composition and undercooling at the surface.

Modeling the phase diagram of carbon.

We determined the phase diagram involving diamond, graphite, and liquid carbon using a recently developed semiempirical potential. Using accurate free-energy calculations, we computed the solid-solid and solid-liquid phase boundaries for pressures and temperatures up to 400 GPa and 12 000 K, respectively. The graphite-diamond transition line that we computed is in good agreement with experimental data, confirming the accuracy of the employed empirical potential.