Publications by authors named "Jan Lippert"
Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
December 2015
Background And Aims: Psoriasis vulgaris (PV) is complicated in up to 40% patients by the inflammatory joint disease psoriatic arthritis (PsA). Neither the aetiology of the arthritis nor specific laboratory markers for its disease activity have been clearly elucidated. Prolactin (PRL) acts as a cytokine with immunomodulatory functions and plays a role in skin and joint biology.
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- The study investigates the effectiveness of using a fractional laser as a pretreatment to enhance the results of photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) for nodular basal cell carcinoma (nBCC).
- In an 18-month clinical trial, patients with nBCC were treated with either a fractional laser or a control method, followed by ALA-PDT, and the responses were evaluated through fluorescence and histopathology.
- Results show that the fractional laser pretreatment led to a higher response rate and increased fluorescence in tumors treated with ALA-PDT, although it also caused longer healing times and more side effects.
Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development.
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- Using noninvasive ultrasound to measure tumor depth allows for effective case selection for laser pre-ablation followed by photodynamic therapy (PDT) to treat basal cell carcinoma (BCC) more gently.
- Basal cell carcinoma mainly appears on the face, making traditional radical excision difficult due to potential cosmetic damage, while PDT is advantageous for its aesthetic outcomes but is limited to tumors shallower than 2 mm.
- The study found a 100% clearance rate for deeper tumors, with high success rates also in medium and shallow tumors, suggesting that ultrasound-guided laser ablation followed by PDT provides an effective treatment option with good aesthetic results.