Publications by authors named "Jan Lammer"
Purpose: Corneal allograft survival is dramatically decreased in high-risk (HR) host beds. The purpose of this study was to investigate the outcome of HR keratoplasty (KP) in a single-center tertiary referral clinic and to determine risk factors for graft failure.
Methods: This retrospective study included adults referred for HR penetrating KP between 2014 and 2022.
Diagnostic performance of corneal epithelium- and Bowman's layer thickness mapping in patients with unilateral Keratoconus.
Graefes Arch Clin Exp Ophthalmol
January 2025
Purpose: To investigate the role of corneal epithelium- and Bowman's layer-thickness (ET and BLT) changes as possible early biomarkers of keratoconus (KC) development.
Methods: In this cross-sectional study patients with unilateral KC (UKC) and a group of healthy controls underwent polarization sensitive optical coherence tomography (PS-OCT) for the evaluation of corneal ET and BLT. These values were compared among three subgroups of eyes, i.
Spotlight on Amniotic Membrane Extract Eye Drops: A Review of the Literature.
Eye Contact Lens
November 2024
Article Synopsis
- The review aimed to assess how effective amniotic membrane extract eye drops (AMEDs) are in treating ocular surface diseases by analyzing existing literature.
- After searching major databases, 12 out of 1,121 initial studies were deemed suitable for analysis, covering various clinical outcomes and methods of preparation for AMEDs.
- The findings suggest that while evidence quality is not perfect, AMEDs provide improvements for patients with conditions like dry eye disease and corneal wounds, reporting a low incidence of side effects.
The purpose of this study was to investigate the role of corneal crosslinking (CXL) of grafts during keratoplasty (KP) in patients with refractory corneal melting (CM). This is a retrospective case series reporting the clinical outcomes of patients who received a crosslinked corneal graft during penetrating or deep anterior lamellar KP for refractory infectious or sterile CMs. Outcome measures were the recurrence of CM, the time required for epithelial healing following KP, incidence of complications, and necessity for re-transplantation.
View Article and Find Full Text PDFPurpose: To review the literature focusing on the clinical outcomes of KeraKlear (KK) (KeraMed), a foldable intrastromal keratoprosthesis.
Methods: We searched 6 databases using 4 keywords: KeraKlear, Foldable Keratoprosthesis, Intrastromal Keratoprosthesis, and Non-penetrating Keratoprosthesis. Included studies had to be conducted in vivo on humans, published until January 3, 2023, and had to investigate the implantation of the KK.
Predictive factors for re-bubbling after DMEK: focus on the posterior corneal surface.
Graefes Arch Clin Exp Ophthalmol
July 2024
Purpose: To understand whether the preoperative morphology of the posterior corneal surface influences the rate of re-bubbling after Descemet membrane endothelial keratoplasty (DMEK).
Methods: After retrospectively analyzing the medical records of patients undergoing DMEK, in this multicentric cross-sectional study, we performed a binomial logistic regression analysis to assess significant predictors of re-bubbling and re-transplantation after surgery. Analyzed parameters included the preoperative diagnosis, anterior and posterior surface K1/K2, central corneal thickness, posterior Q value, and other posterior corneal surface parameters evaluated on the elevation maps produced by anterior segment optical coherence tomography.
Article Synopsis
- Corneal vascularization (CV) can compromise the cornea's ability to heal and increase the risk of rejection after corneal transplants (keratoplasty), making reliable imaging methods important for pre-surgical evaluation.
- This study assessed the effectiveness of Anterior Segment Optical Coherence Tomography Angiography (AS-OCTA) in visualizing and quantifying CV compared to traditional slit-lamp photography in high-risk eyes.
- Findings indicated that AS-OCTA provided clearer and more detailed images of vascular structures and metrics related to CV, suggesting it could be an essential tool for monitoring and guiding treatment before keratoplasty.
Bilateral corneal perforation in Ipilimumab/Nivolumab - associated peripheral ulcerative keratitis.
Am J Ophthalmol Case Rep
December 2022
Article Synopsis
- A 60-year-old man undergoing treatment for metastatic melanoma with Ipilimumab and Nivolumab developed severe eye issues, specifically bilateral peripheral ulcerative keratitis, which led to corneal perforation.
- Initial symptoms included a foreign body sensation and tearing, but traditional anti-inflammatory treatments failed, necessitating further surgical interventions.
- The case highlights how immune checkpoint inhibitors can disrupt corneal immunity, resulting in serious autoimmune complications in the eyes.
Introduction: This study aimed to test and evaluate modified corneal cross-linking (CXL) protocols regarding improved treatment effects on the peripheral cornea in terms of tissue stability and cellular response.
Methods: Peripheral CXL (pCXL) was performed within a ring of 9-11 mm of 36 human donor corneas with variations in applied energy (5.4, 7.
Article Synopsis
- The study investigates changes in the corneal epithelium and nerves in patients with refractory/relapsed multiple myeloma undergoing treatment with belantamab mafodotin (belamaf).
- The research involved BCVA testing and corneal confocal microscopy to measure nerve fiber density and other metrics before and during treatment.
- Results showed a significant deterioration in visual acuity and severe damage to corneal nerve structures, indicating neurotoxic effects of belamaf on the human cornea.
Atezolizumab induced immune-related adverse event mimicking conjunctival metastatic disease.
Am J Ophthalmol Case Rep
June 2022
Purpose: To describe a case of an immune-related adverse event associated with Atezolizumab therapy which was aggravated by ocular surgery.
Observations: A 59-year-old man treated with Atezolizumab for metastatic non-small-cell lung cancer developed a conjunctival hypertrophic lesion mistaken for metastatic tissue. Biopsy surgery induced fulminant and multifocal granulomatous conjunctival tissue growth and sterile corneal ulceration.
Purpose: To assess grading reproducibility of disorganization of the retinal inner layers (DRIL) and other morphologic features of diabetic macular edema (DME) across spectral domain optical coherence tomography (SDOCT) instruments and scan types.
Methods: A cross-sectional study enrolled participants with current or recent center-involved DME. In group A (27 eyes), we obtained two Cirrus scans (512 × 128 macular cube [Cube] and high-definition five-line raster [HD 5-Line]) and two Spectralis scans (high-resolution [HR] and high-speed [HS]).
Purpose: To assess endothelial safety and efficacy of ex vivo corneal collagen cross-linking (CXL) in human corneal transplants stored in 2 different culture media.
Design: Fellow-eye controlled laboratory study of ex vivo human donor corneas.
Methods: Three sets of paired human donor corneas, 5 pairs each, were stored in organ culture medium before deswelling either at 31 C or at room temperature.
Article Synopsis
- The study evaluated the effectiveness of two imaging methods—Topcon Atlantis SS-OCT and Heidelberg Spectralis FDI—in diagnosing diabetic macular oedema (DME).
- Two graders assessed various DME characteristics, including cyst sizes and fluid presence, and statistically analyzed their findings.
- Results showed significant differences in measurements between the two devices for certain features, indicating the need for consistency in using the same device for monitoring DME in clinical assessments.
Purpose: To investigate the efficacy of corneal crosslinking (CXL) for pellucid marginal degeneration (PMD).
Setting: Medical University of Vienna.
Design: Retrospective study.
Purpose: To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.
Design: Cross-sectional study.
Methods: Setting: institutional.
Purpose: We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT).
Methods: Diabetic participants underwent VA testing and AOSLO and SDOCT imaging of MAs. AOSLO images were graded for MA dimension, wall hyperreflectivity (WH), intraluminal hyperreflectivity (IH), and perfusion pattern.
Purpose: We demonstrate segmentation and mapping of corneal layers (epithelium, Bowman's layer, and stroma) across the entire cornea (limbus to limbus), using additional contrast provided by polarization-sensitive optical coherence tomography (PS-OCT) and analyze the reproducibility of the procedure.
Methods: A custom built PS-OCT system operating at 1045 nm central wavelength with conical scanning was used for image acquisition. Conical scanning allows for almost perpendicular beam incidence on the corneal surface and provides good signal quality over the entire field of view.
Purpose: To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques.
Methods: Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR.
Importance: Anti-vascular endothelial growth factor treatment is the first-line therapy in the treatment of center-involving diabetic macular edema. Data on capillary perfusion changes under repeated treatment in a possibly compromised vascular network are limited.
Objective: To evaluate the association of repeated ranibizumab injections on macular perfusion in patients with diabetic macular edema.
Correlation between central stromal demarcation line depth and changes in K values after corneal cross-linking (CXL).
Graefes Arch Clin Exp Ophthalmol
April 2018
Purpose: A stromal demarcation line (DL) after corneal cross-linking (CXL) has lately been suggested as a surrogate parameter for the success of CXL. The aim of this study was to investigate the correlation between depth of the central DL 1 month and the change in K values 12 months after CXL.
Methods: Treatment-naive subjects with keratoconus were treated using an accelerated CXL protocol [A-CXL(9*10)].
Purpose: To find differences in epithelial thickness (ET) maps of eyes with keratoconus (KC) and healthy eyes.
Design: Institutional cross-sectional study.
Methods: In this study 40 keratoconic eyes and 76 healthy eyes were scanned using a custom-built ultrahigh-resolution optical coherence tomography system.
Purpose: Our purpose was to compare the impact in diabetic macula edema (DME) of two intravitreal drugs (0.5 mg ranibizumab vs. 8 mg triamcinolone) on changes in retinal morphology in spectral-domain optical coherence tomography (SD OCT) images, color fundus photography (CF) and fluorescein angiography (FA) images during a 1-year follow-up.
View Article and Find Full Text PDFPurpose: To evaluate detailed changes in retinal layer thickness in spectral-domain optical coherence tomography (SD-OCT) images during a 1-year follow-up of patients treated for diabetic macula oedema (DME).
Methods: Post hoc analysis of retinal layer thickness changes applying the automated layer segmentation of SD-OCT images in eyes with DME that were randomly assigned to receive pro re nata (PRN) treatment with either 0.5 mg ranibizumab or 8 mg triamcinolone.