Publications by authors named "Jan Koeleman"
Article Synopsis
- Dexamphetamine (AMPH) is a psychostimulant used for both recreational purposes and the treatment of ADHD, but repeated exposure can harm dopamine (DA) neuron terminals.
- A study conducted on rats showed that those pre-treated with AMPH had a heightened BOLD response in DA-related brain areas during a methylphenidate (MPH) challenge, indicating altered DAergic functions.
- Further analyses indicated reduced DA transporter density and increased DA metabolites, suggesting that AMPH alters dopamine release and binding, highlighting phMRI's potential as a non-invasive tool for studying dopamine-related changes in drug research and neuropsychiatric conditions.
Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF and CRF receptor mRNA. Furthermore, the ascending NI relaxin-3 system is implicated in alcohol seeking in rats.
View Article and Find Full Text PDFBackground: Cortical gray matter (GM) demyelination is frequent and clinically relevant in multiple sclerosis (MS). Quantitative magnetic resonance imaging (qMRI) sequences such as magnetization transfer ratio (MTR) and quantitative R2* (qR2*) can capture pathological subtleties missed by conventional magnetic resonance imaging (MRI) sequences. Although differences in MTR and qR2* have been reported between lesional and non-lesional tissue, differences between lesion types or lesion types and myelin density matched normal-appearing gray matter (NAGM) have not been found or investigated.
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