Publications by authors named "Jan Holly-Nicolas"
Background: Warfarin is associated with poor outcomes after trauma, an effect correlated with elevations in the international normalized ratio (INR). In contrast, the novel oral anticoagulants (NOAs) have no validated laboratory measure to quantify coagulopathy. We sought to determine if use of NOAs was associated with elevated activated partial thromboplastin time (aPTT) or INR levels among trauma patients or increased clotting times on thromboelastography (TEG).
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- The study examined the impact of novel oral anticoagulants (NOAs) on trauma outcomes, particularly focusing on intracranial hemorrhage (ICH) in comparison to traditional anticoagulants and antiplatelets.
- A total of 1,847 trauma patients were enrolled, finding that those on NOAs had similar ICH rates and mortality compared to other anticoagulant groups.
- The research concluded that patients using NOAs were not at a significantly higher risk for ICH or death, which challenges previous concerns regarding their safety in trauma situations.