Publications by authors named "Jan Hoelzl"
Article Synopsis
- The study examines how variations in tumor microenvironments (TMEs) affect cancer progression by analyzing 52 head and neck squamous cell carcinomas.
- It identifies macrophage polarity—determined by CS expression—as a significant factor for prognosis, rather than traditional M1 and M2 classifications.
- The findings indicate that TMEs create organized networks of pro- and antitumor responses, emphasizing that CS macrophage polarity could simplify understanding complex cancer behaviors across different types of tumors.
Cellular analyses are increasingly used to diagnose diseases at point-of-care and global healthcare settings. Some analyses are simple as they rely on chromogenic stains (blood counts, malaria) but others often require higher multiplexing to define and quantitate cell populations (cancer diagnosis, immunoprofiling). Simplifying the latter with inexpensive solutions represents a current bottleneck in designing start-end pipelines.
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