Publications by authors named "Jan Henrik Schlattjan"
Gender differences in renal tubular taurocholate transport.
Naunyn Schmiedebergs Arch Pharmacol
June 2005
Article Synopsis
- Bile acids are mostly reabsorbed in the kidneys and not excreted in urine, primarily through a sodium-dependent transporter called ASBT in proximal tubular cells.
- Male and female rats show significant differences in the accumulation and clearance of taurocholate, with males exhibiting higher uptake and clearance rates.
- Estrogen appears to inhibit taurocholate transport in male rats, while testosterone treatment does not significantly affect female rats, suggesting that sex hormones play a role in how kidneys handle bile acids.
Background/aims: The bile acids filtered through the glomeruli nearly completely escape urinary excretion due to an efficient tubular reabsorption process. Reabsorption is mediated mainly by the sodium-dependent bile acid transporter (ASBT) which is located in the brush border membranes of proximal tubular cells. The present study addresses the question whether this transporter is subject to short-term regulation by protein kinases.
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- The study investigates the impact of the bile acid analogue S 0960, which inhibits the apical sodium-dependent bile salt transporter (ASBT), on kidney function in rats.
- After administering S 0960, there was a significant increase in 3H-taurocholate clearance and a decrease in its tubular reabsorption, while glomerular filtration rate remained stable.
- Isolated proximal tubular cells showed marked 3H-taurocholate accumulation, and the study highlighted that sodium-dependent transport mechanisms play a crucial role in this process.
Background/aims: In obstructive liver diseases, urinary excretion of bile acids is markedly enhanced. The mechanism of this effect is not entirely clear. The aim of the present study was to assess the glomerular and tubular factors involved in the renal handling of bile acids during the early phase of an obstructive cholestasis induced by a 24-hour bile duct ligation in rats.
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