A new polymer-excipient for ethanol-resistant, sustained-release oral dosage forms.

The use of alcoholic beverages can cause uncontrolled release of drugs from sustained-release solid oral dosage forms and pose severe risks to patient health. The aim of this work was to design a new polymeric excipient with ethanol resistance inherent to the polymer. Polymers were systematically designed, manufactured via emulsion polymerization, and fully characterized.

Toward pH-responsive coating materials--high-throughput study of (meth)acrylic copolymers.

The release behavior of a model compound (β-naphthol orange) encapsulated in (meth)acrylate-based statistical copolymers under different environmental conditions was investigated. From monomers of varying polarity (methyl acrylate, ethyl acrylate, tert-butyl acrylate, 2-ethylhexyl methacrylate, and benzyl methacrylate) in combination with methacrylic acid, five polymer series were synthesized by free radical polymerization. The pH-dependent release kinetics were investigated via UV-vis spectroscopy at pH 1.