Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.

Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the arfaptins have recently been demonstrated to coordinate the budding and formation of immature secretory granules (ISGs) at the trans-Golgi network. Here, we identify 4 coding variants in the PICK1 gene from a whole-exome screening of Danish patients with diabetes that each involve a change in positively charged residues in the PICK1 BAR domain.

First Evidence That Nematode Communities in Deadwood Are Related to Tree Species Identity and to Co-Occurring Fungi and Prokaryotes.

Nematodes represent a diverse and ubiquitous group of metazoans in terrestrial environments. They feed on bacteria, fungi, plants, other nematodes or parasitize a variety of animals and hence may be considered as active members of many food webs. Deadwood is a structural component of forest ecosystems which harbors many niches for diverse biota.

Study of the Performance of DSSS UAC System Depending on the System Bandwidth and the Spreading Sequence.

A signal transmitted in an Underwater Acoustic Communication (UAC) system operating in a shallow-water channel suffers from strong time dispersion due to multipath propagation. This causes the Inter-Symbol Interference (ISI) observed in the received signal, which significantly limits the communication system's reliability and transmission rate. In such propagation conditions, the Direct-Sequence Spread Spectrum (DSSS) method is one of the solutions that make reliable data transmission possible.

Cover crops and compost prevent weed seed bank buildup in herbicide-free wheat-potato rotations under conservation tillage.

Weeds are a major constraint affecting crop yields in organic farming and weed seed bank analysis can be an important tool for predicting weed infestation and assessing farming system sustainability.We compared the weed seed banks two and four years after transition from conventional to reduced tillage in organically managed winter wheat-potato cropping sequences in two replicated field trials. Experimental factors were either conventional (CT) with moldboard (25 cm) or reduced tillage (RT) with chisel ploughing (5-15 cm).