Publications by authors named "Jan H Dillingh"
Article Synopsis
- Phelan-McDermid syndrome (PMS) is a rare disorder primarily affecting cognitive and behavioral development in children and some adults, with notable impacts on intellectual disability and autistic behaviors.
- A pilot study suggested that intranasal insulin might improve development and behavior in children with PMS, prompting a larger clinical trial to validate these findings.
- The trial involved 25 children over 18 months, showing some improvement in developmental functioning with intranasal insulin, especially in children over 3 years old, but statistically significant results were not achieved, indicating a need for further research with larger groups.
Low-toxicity conditioning regimens prior to bone marrow transplantation (BMT) are widely explored. We developed a new protocol using hematopoietic growth factors prior to low-dose total body irradiation (TBI) in recipients of autologous transplants to establish high levels of long-term donor cell engraftment. We hypothesized that treatment of recipient mice with growth factors would selectively deplete stem cells, resulting in successful long-term donor cell engraftment after transplantation.
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