Publications by authors named "Jan G Gleixner"
Article Synopsis
- Scientists studied how aging affects inflammation in the intestines of mice by looking at different types of cells.
- They discovered that older intestinal stem cells change in a way that promotes inflammation, and this change can be passed on through cell cultures.
- The researchers also found that a specific signaling pathway (STAT1) plays a key role in how these inflammation-related genes are activated.
The activity of proteins is dictated by their three-dimensional structure, the native state, and is influenced by their ability to remain in or return to the folded native state under physiological conditions. Backbone circularization is thought to increase protein stability by decreasing the conformational entropy in the unfolded state. A positive effect of circularization on stability has been shown for several proteins.
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