Publications by authors named "Jan Engel"
Background: Magnetic resonance imaging (MRI) followed by targeted biopsy (TBx) is utilized for prostate cancer (PCa) detection. However, the value of adding systematic biopsies (SBx) to targeted biopsy procedures (combined biopsy; CBx) in men with suspicious MRI findings has not been determined.
Methods: We analysed biopsy outcomes in 429 men with MRI lesions in the prospective multicenter STHLM3MRI pilot study, planned for prostate biopsy.
Article Synopsis
- - This study focuses on how elevated atmospheric CO levels (eCO) affect plant carbon assimilation and water usage, impacting global carbon and water cycles.
- - Researchers use a land surface model called QUINCY to simulate the effects of increasing CO on plant physiology and to develop a statistical method for detecting these effects amid natural variations in ecosystems.
- - Findings show that eCO effects on carbon productivity can be detected at lower CO increases compared to their effects on water use, with stronger signals in forest ecosystems than in grasslands, providing insight for future observational studies.
Background: Pulmonary tumour embolism and lymphangitis carcinomatosa are complications of malignancy that may mimic the clinical presentation of pulmonary embolism.
Case Presentation: We present the case of a 52-year-old male patient with acute-onset right ventricular strain and dyspnoea with elevated D-dimer and without signs of pulmonary embolism on computed tomography pulmonary angiogram (CTPA) and ventilation/perfusion scintigraphy. The patient died eleven days after initial presentation.
Identifying Prostate Cancer Among Men with Lower Urinary Tract Symptoms.
Eur Urol Open Sci
February 2021
Article Synopsis
- In men over 50, lower urinary tract symptoms (LUTS) and prostate conditions like benign prostate hyperplasia and prostate cancer are prevalent, prompting guidelines for prostate-specific antigen (PSA) testing in those with LUTS for cancer detection.
- A study analyzed data from 4,588 men aged 50-69 with moderate LUTS and elevated PSA levels, comparing the effectiveness of PSA, PSA density, and the Stockholm3 blood test in identifying significant prostate cancer (sPCa).
- Results showed the Stockholm3 test was significantly better than PSA density and PSA at identifying sPCa, but limiting biopsies to men with higher PSA levels would miss a large percentage of detectable cancers, suggesting a careful balance in biopsy recommendations
Acanthamoebae are facultative parasites causing rare but serious infections such as keratitis and encephalitis and are also known as vectors for several bacterial pathogens, including legionellae and pseudomonads. Acanthamoeba cysts are particularly resilient and enable the amoebae to withstand desiccation and to resist disinfection and therapy. While the search for new therapeutic options has been intensified in the past years, hand and surface disinfectants as well as topical antiseptics for preventing infections have not been studied in detail to date.
View Article and Find Full Text PDFBackground: Compliance to long-term ambulatory electrocardiogram monitoring is important for diagnosis in patients with cardiac arrhythmia. This requires a system with a minimal impact on daily activities.
Objective: The aim of this study was to investigate if a lightweight integrated adhesive monitor for long-term use without unacceptable adverse effects is feasible.