A randomized trial of methotrexate versus azathioprine for severe atopic eczema.

Background: Patients with severe atopic eczema frequently require systemic treatment to control their disease. Methotrexate and azathioprine are proposed as off-label treatment options, but direct comparisons are lacking.

Objectives: We sought to compare the efficacy and safety of methotrexate versus azathioprine in adults with severe atopic eczema.