SAFIR-I: first NEMA NU 4-2008-based performance characterization.

Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a novel Positron Emission Tomography insert for a [Formula: see text] Bruker BioSpec 70/30 Ultra Shield Refrigerated Magnetic Resonance Imaging (MRI) system. It facilitates truly simultaneous quantitative imaging in mice and rats at injected activities as high as [Formula: see text]. Exploitation of the resulting high count rates enables quick image formation at few seconds per frame.

SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI.

(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.

TRAIL-receptor 2-a novel negative regulator of p53.

TNF-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2) can induce apoptosis in cancer cells upon crosslinking by TRAIL. However, TRAIL-R2 is highly expressed by many cancers suggesting pro-tumor functions. Indeed, TRAIL/TRAIL-R2 also activate pro-inflammatory pathways enhancing tumor cell invasion, migration, and proliferation.