Publications by authors named "Jan D Quell"
Kit-based assays, such as Absolute p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs). Many disease-relevant associations of PCs were reported using this method. However, their interpretation is hampered by lack of functionally-relevant information on the detailed fatty acid side-chain compositions as only the total number of carbon atoms and double bonds is identified by the kit.
View Article and Find Full Text PDFAutomated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2017
Article Synopsis
- Identification of unknown metabolites in large human studies poses a challenge in metabolomics, requiring robust identification methods for further analysis.
- A new systems biology model integrates correlation data from metabolite levels, along with existing genetic and biochemical information, to better characterize unknown metabolites in blood samples from 2279 subjects.
- The study led to successful predictions and classifications of 180 unknown metabolites and ultimately confirmed two of them through LC-MS analyses, illustrating the model's effectiveness in metabolite identification.