Impact of Selective Reporting of Antibiotic Susceptibility Test Results on Antibiotic Use in Patients with Bloodstream Infection with .

Introduction: Invasive pneumococcal disease is a major cause of morbidity and mortality in infectious diseases. Selective reporting of antibiotic susceptibility test results might lead to a tailored antibiotic therapy and could therefore be an important antibiotic stewardship program intervention. The aim of this study was to analyse whether a switch to selective reporting of antibiotic test results leads to a more focused antibiotic therapy in patients with a bloodstream infection with .

De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.

FRY-like transcription coactivator (FRYL) belongs to a Furry protein family that is evolutionarily conserved from yeast to humans. The functions of FRYL in mammals are largely unknown, and variants in FRYL have not previously been associated with a Mendelian disease. Here, we report fourteen individuals with heterozygous variants in FRYL who present with developmental delay, intellectual disability, dysmorphic features, and other congenital anomalies in multiple systems.

Context matters: athletes' perception of dopers' values, actions and vulnerabilities.

Background: Although athletes seem to hold uniform views towards non-dopers, their perception of dopers is more nuanced, reflecting positive and negative attributes. Research also indicates that rarely a single factor can explain doping, but a host of reasons that intertwine. A holistic understanding of how values play a role in decisions in anti-doping and the elements that influence athletes' doping vulnerability is timely and warranted.

Deliriogenic Medication Prescribing and Delirium in Hospitalized, Non-Critically Ill Older People.

Describe the incidence of delirium and associated outcomes among hospitalized, non-critically ill older people. Single-center, retrospective chart review. A 217-bed academic teaching hospital in Cambridge, Massachusetts affiliated with Harvard Medical School.

Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry.

The breaking of bilateral symmetry in most vertebrates is critically dependent upon the motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid flow; however, it remains unclear how this flow is sensed. Here, we demonstrated that immotile LRO cilia are mechanosensors for shear force using a methodological pipeline that combines optical tweezers, light sheet microscopy, and deep learning to permit in vivo analyses in zebrafish. Mechanical manipulation of immotile LRO cilia activated intraciliary calcium transients that required the cation channel Polycystin-2.

Effect of practice on learning a balance task in children, adolescents, and young adults.

Background: A lower developmental stage of the postural control system in childhood compared to adolescence and adulthood was reported in numerous studies and suggests differences (i.e., less improvements in children than in adolescents and young adults due to the immature postural control system) during learning a balance task.

Effect of Arm Movement and Task Difficulty on Balance Performance in Children, Adolescents, and Young Adults.

Background: Studies have shown that restricted compared to free arm movement negatively affects balance performance during balance assessment and this is reinforced when the level of task difficulty (e.g., varying stance/walk conditions, sensory manipulations) is increased.

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.

For more than 100 years, the fruit fly has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula , that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal.

Avoided Hospitalization Criteria: Validating the Impact of a Community-Based Palliative Care Program.

This report describes the experiences of a community-based palliative care (CBPC) program's efforts to understand the patterns of hospital utilization, specifically utilization reduction experienced by admitted patients. Efforts to quantify and describe an avoided hospitalization and opportunities to use these data to strengthen partnerships with local insurance payers to assure sustainability of the CBPC will be discussed. Patients with serious chronic illness experience emergency room care and hospitalizations with increasing frequency as their health deteriorates.

Wakefulness impairs selective consolidation of relevant trauma-associated memories resulting in more frequent intrusions.

Recent studies show that sleep reduces intrusive memories after analog trauma. This effect is assumed to be caused by sleep's impact on memory consolidation. However, the underlying processes of this phenomenon have not been uncovered.

Effects of Motor Versus Cognitive Task Prioritization During Dual-Task Practice on Dual-Task Performance in Young Adults.

: Previous studies have reported positive effects of concurrent motor and cognitive task practice compared to motor or cognitive task practice only on dual-task performance in young adults. Knowledge about the effect of motor vs. cognitive task prioritization during practice on dual-task performance remains unclear and has not been investigated in depth so far.

Effect of practice on learning to maintain balance under dynamic conditions in children: are there sex differences?

Background: In youth, sex-related differences in balance performances have been reported with girls usually outperforming same-aged boys. However, it is not known whether sex also has an influence on learning of a new balance task in primary school-aged children. Therefore, the present study investigated sex-related differences in children learning to maintain balance under dynamic conditions.

Patterned remittances enhance women's health-related autonomy.

The consequences for women "left behind" by virtue of temporary male migration are mixed. On the one hand, concomitant changes in fertility, participation in the labor force, and social norms are often associated with increased independence for women. On the other hand, women left behind can be vulnerable to increased dependency on members of their husbands' family or face limited access to social institutions.

Confocal Volumetric μXRF and Fluorescence Computed μ-Tomography Reveals Arsenic Three-Dimensional Distribution within Intact Fronds.

The fern has been the subject of numerous studies because of its extreme arsenic hyperaccumulation characteristics. However, information on the arsenic chemical speciation and distribution across cell types within intact frozen-hydrated fronds is necessary to better understand the arsenic biotransformation pathways in this unusual fern. While 2D X-ray absorption spectroscopy imaging studies show that different chemical forms of arsenic, As(III) and As(V), occur across the plant organs, depth-resolved information on arsenic distribution and chemical speciation in different cell types within tissues of have not been reported.

Effects of a blocked versus an alternated sequence of balance and plyometric training on physical performance in youth soccer players.

Background: The sequence of blocked balance training (BT) followed by blocked plyometric training (PT) showed greater improvements in physical performance than vice versa and is explained by a preconditioning effect of BT-related adaptations on subsequent adaptations induced by PT. However, it remains unclear whether beneficial effects can also be induced using alternating instead of blocked BT and PT exercise sequences. Thus, we examined the effects of a blocked versus an alternated sequence of BT and PT on physical performance in trained individuals.

Differential effects of sleep on explicit and implicit memory for potential trauma reminders: findings from an analogue study.

: Recent findings suggest that disruptions of sleep-related memory processing are involved in the development of posttraumatic stress symptoms. More specifically, exposure to an analogue traumatic event resulted in fewer intrusive memories, when it was followed by sleep instead of continued wakefulness. However, competing evidence suggests that sleep deprivation may reduce intrusive re-experiencing.

The Prospective Influence of Trait Alexithymia on Intrusive Memories: What Is the Role of Emotional Recognition Memory?

Posttraumatic stress disorder (PTSD) is often considered to be a disorder of memory as patients suffer from fragmented uncontrollable memories (intrusions) whilst experiencing difficulties in intentionally retrieving details of the traumatic event. Recent research suggests that trait-related deficits in the identification of emotional states (alexithymia) may impact emotional memory processes in a way that promotes intrusion formation in PTSD. Therefore, we investigated the influence of alexithymia on intrusive re-experiencing and emotional recognition memory in a prospective analog study.

Limb Differences in Unipedal Balance Performance in Young Male Soccer Players with Different Ages.

In soccer, the dominant leg is frequently used for passing and kicking while standing on the non-dominant leg. Consequently, postural control in the standing leg might be superior compared to the kicking leg and is further enhanced with increasing age (i.e.

CHRAC/ACF contribute to the repressive ground state of chromatin.

The chromatin remodeling complexes chromatin accessibility complex and ATP-utilizing chromatin assembly and remodeling factor (ACF) combine the ATPase ISWI with the signature subunit ACF1. These enzymes catalyze well-studied nucleosome sliding reactions in vitro, but how their actions affect physiological gene expression remains unclear. Here, we explored the influence of chromatin accessibility complex/ACF on transcription by using complementary gain- and loss-of-function approaches.