Publications by authors named "Jan Braune"

Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, and better risk stratification as well as new therapies are therefore highly needed. The proteome of MM has not been systematically assessed before and holds the potential to uncover insight into disease biology and improved prognostication in addition to genetic and transcriptomic studies.

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Article Synopsis
  • Tissue-resident lymphocytes play a crucial role in defending organs against pathogens, but their response to vaccines in humans is less understood.
  • A study analyzed SARS-CoV-2 mRNA vaccine-specific T cells from various organs and blood of largely virus-naive individuals, revealing higher numbers of specific CD4+ T cells in nonlymphoid tissues compared to blood.
  • Findings suggest that vaccination leads to the development of memory T cells in organs far from the vaccination site, enhancing local immune protection in those tissues.
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The majority of patients with acute myeloid leukemia (AML) with the mutation achieve remission with intensive chemotherapy. However, many patients subsequently relapse, which occurs frequently within the first 2-3 years after therapy, while late relapse after more than 10 years is rare and can also represent secondary/therapy-associated AML without the NPM1 mutation. Here, we present a case of -mutated AML that developed medullary and extramedullary relapse 17 years after allogeneic stem cell transplantation, maintaining the mutation and all other genetic alterations detected at first diagnosis.

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Proteasome inhibition is a highly effective treatment for multiple myeloma (MM). However, virtually all patients develop proteasome inhibitor resistance, which is associated with a poor prognosis. Hyperactive small ubiquitin-like modifier (SUMO) signaling is involved in both cancer pathogenesis and cancer progression.

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Purpose: We evaluated circulating tumor DNA (ctDNA) for detecting tumor burden in melanoma and examined whether early changes in the number of ctDNA copies predict response to treatment.

Patients And Methods: We included 12 patients with stage III and 50 patients with stage IV melanoma with exon 15 or exon 3 mutations in tumor tissue. We used droplet digital polymerase chain reaction to retrospectively analyze serial plasma samples for mutation-positive ctDNA.

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Background: Circulating tumor DNA (ctDNA) in the blood plasma of cancer patients is an emerging biomarker used across oncology, facilitating noninvasive disease monitoring and genetic profiling at various disease milestones. Digital droplet PCR (ddPCR) technologies have demonstrated high sensitivity and specificity for robust ctDNA detection at relatively low costs. Yet, their value for ctDNA-based management of a broad population of cancer patients beyond clinical trials remains elusive.

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