Publications by authors named "Jan Bayram"
Active wound dressings are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected skin wound healing. As the wide use of antibiotics leads to drug resistance we present here a new concept of wound dressings based on the polycaprolactone nanofiber scaffold (NANO) releasing second generation lipophosphonoxin (LPPO) as antibacterial agent. Firstly, we demonstrated in vitro that LPPO released from NANO exerted antibacterial activity while not impairing proliferation/differentiation of fibroblasts and keratinocytes.
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- Pathogenic Leptospira spp. cause leptospirosis and face challenges like reactive oxygen species (ROS) from host immunity, necessitating evolved defenses for persistence.
- The study used RNA sequencing to assess how L. interrogans responds to varying levels of hydrogen peroxide and to identify the role of the peroxide stress regulator, PerR, in managing oxidative stress.
- Key findings include the involvement of specific peroxidase enzymes, heat shock response proteins, and a PerR-independent regulatory network that aids in Leptospira’s tolerance to oxidative damage, potentially revealing new avenues for understanding its virulence strategies.
Bordetella bronchiseptica and Bordetella pertussis are closely related respiratory pathogens that evolved from a common bacterial ancestor. While B. bronchiseptica has an environmental reservoir and mostly establishes chronic infections in a broad range of mammals, B.
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