Publications by authors named "Jan A H Danser"
Article Synopsis
- Creatine kinase is linked to blood pressure regulation, as it helps generate ATP which is crucial for muscle contraction and sodium retention in the kidneys.
- In a study with hypertensive rats, researchers tested a creatine kinase inhibitor, beta-guanidinopropionic acid, over four weeks to see its effects on blood pressure.
- Results showed that inhibiting creatine kinase significantly lowered blood pressure, improved blood vessel dilation, and had a diuretic effect, suggesting it could be a new treatment option for hypertension.
Role of endothelin in preeclampsia and hypertension following antiangiogenesis treatment.
Curr Opin Nephrol Hypertens
March 2016
Purpose Of Review: Preeclampsia is a systemic, pregnancy-related disorder featuring hypertension and proteinuria arising from placental overproduction of soluble FMS-like tyrosine kinase-1, resulting in an antiangiogenic state because of the inhibition of the vascular endothelial growth factor (VEGF) family. Similarly, antiangiogenetic treatment aimed at targeting VEGF in patients with cancer is associated with a preeclampsia-like syndrome. In this study we discuss the pathophysiological role of an activated endothelin system in both conditions.
View Article and Find Full Text PDFObesity is a major risk factor for the development of hypertension. Because the prevalence of obesity is increasing worldwide, the prevalence of obesity hypertension is also increasing. Importantly, hypertension in obesity is commonly complicated by dyslipidemia and type 2 diabetes mellitus and hence imposes a high cardiovascular disease risk.
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