Publications by authors named "Jamshaid A Siddiqui"
Poly [adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are members of a family of 17 enzymes that performs several fundamental cellular processes. Aberrant activity (mutation) in PARP12 has been linked to various diseases including inflammation, cardiovascular disease, and cancer. Herein, a large library of compounds (ZINC-FDA database) has been screened virtually to identify potential PARP12 inhibitor(s).
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- Cytokines like TNF-α and TNF-β are important in regulating the immune response and can influence cancer progression, including breast cancer, though their exact roles remain unclear.
- A study of 150 breast cancer patients and 300 healthy controls in North India found a significant association of the TNF-α-308 G/A polymorphism with breast cancer, but no association was identified for TNF-β +252 A/G.
- Results indicate that the A allele of TNF-α-308 G/A may be linked to breast cancer susceptibility, while the GG genotype of TNF-β +252 A/G appears more prevalent in higher-grade cancer patients.
This study was undertaken with the primary aim of analyzing the clinical relevance of posttransplant appearance of anti-human leukocyte antigen (HLA) and major histocompatibility (MHC) class I related chain A (MICA) antibodies in response to live related donor (LRD) renal transplantation. A total of 185 consecutive post renal transplant recipient serum samples were analyzed for the detection of anti-HLA by enzyme-linked immunoabsorbent assay (ELISA) and MICA antibodies using Luminex techniques. Patients with IgG HLA class I antibodies had more acute rejection episodes compared to the negative group (67% vs.
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