Publications by authors named "Jamin Byun"
The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance of DNMT3A-destabilizing mutations (DNMT3A) in AML, we here investigate the common characteristics of DNMT3A AML methylomes through computational analyses. We present that methylomes of DNMT3A AMLs are considerably different from those of DNMT3A AMLs in that they exhibit increased intratumor DNA methylation heterogeneity in bivalent chromatin domains.
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- This study investigates the link between lysosomal dysfunction and pancreatic ductal adenocarcinoma (PDAC), focusing on germline variants in genes related to lysosomal storage diseases (LSD) among patients and healthy individuals.
- Researchers found that patients with PDAC had a significantly higher prevalence of putative pathogenic variants in LSD-related genes compared to healthy controls, and those with these variants were generally younger.
- Further analysis revealed that downregulation of the lysosomal enzyme galactosylceramidase (GALC) impacted autophagic activity and increased cell proliferation in pancreatic organoids, suggesting that GALC variants could contribute to drug resistance and altered metabolic pathways in PDAC.