Performance of Busulfan Dosing Guidelines for Pediatric Hematopoietic Stem Cell Transplant Conditioning.

Achievement of a busulfan area-under-the-concentration versus time curve (AUC) of 900 to 1500 μM·min is associated with improved hematopoietic stem cell transplant (HSCT) outcomes. Multiple pediatric busulfan dosing guidelines aim to achieve this target. The authors' objective was to describe the AUCs achieved after simulated dosing using available pediatric i.

Using nitrofurantoin while breastfeeding a newborn.

Question: My patient has a urinary tract infection and is currently breastfeeding. Her son is only 3 weeks old. Is nitrofurantoin a safe antibiotic for treatment?

Answer: The use of nitrofurantoin in breastfeeding mothers is generally safe, as only small amounts transfer into the breast milk.

Pregnancy and neonatal outcomes of aboriginal women: a systematic review and meta-analysis.

Purpose: inadequate prenatal care and higher incidences of higher-risk behaviors and gestational diabetes, in addition to other significant determinants of health, place aboriginal women at increased risk of adverse pregnancy outcomes. We conducted a systematic review and meta-analyses of pregnancy and neonatal outcomes among aboriginal women.

Methods: we searched Medline, Embase, and CINAHL for English-language studies reporting rates of pregnancy and neonatal outcomes among aboriginal women.

Maternal marital status and birth outcomes: a systematic review and meta-analyses.

Systematically review risks of an infant being born with low birth weight (LBW), preterm birth (PTB) or small for gestational age (SGA) among married and unmarried women. Medline, Embase, CINAHL, and bibliographies of identified articles were searched for English language studies. Studies reporting birth outcomes of married and unmarried (single and cohabitant) were included.