The Science of Developing Appealing Flavors to Drive Compliance.

Objectives: To develop flavors for oral care formulations containing zinc oxide, zinc citrate and L-arginine that are stable for the toothpaste shelf life, mask the unpleasant astringency and metallic off notes of the base, have an appealing taste which pleases global consumers, stimulate regimen compliance, and therefore help deliver whole mouth health benefits to people throughout the world.

Methods: For stability evaluation, flavor materials were formulated in Dual Zinc plus Arginine base and these samples were subjected to accelerated aging which consists of exposure to a temperature of 49°C for 6 weeks. The samples were analyzed by gas chromatography with flame ionization detector (GC FID) and gas chromatography mass spectrometry (GC MS) to confirm stability or establish changes in the chemical profile - loss of material and generation of degradation compounds.